(R)-1-Chloro-2-propanol

Base Information

• Chemical Name: (R)-1-Chloro-2-propanol
• CAS No.: 19141-39-0
• Molecular Formula: C3H7ClO
• Molecular Weight: 94.541
• Hs Code.: 2905590090
• European Community (EC) Number: 686-912-5
• Nikkaji Number: J51.880H
• Mol file: 19141-39-0.mol

Synonyms:(R)-1-Chloro-2-propanol;19141-39-0;(R)-1-chloropropan-2-ol;(2R)-1-chloropropan-2-ol;2-Propanol, 1-chloro-, (2R)-;MFCD01862132;2-Propanol, 1-chloro-, (2R)- (9CI);YYTSGNJTASLUOY-GSVOUGTGSA-N;(A+/-)-1-chloro-propan-2-ol;(R)-(-)-1-chloro-2-propanol;[R,(+)]-1-Chloro-2-propanol;AKOS006277704;AKOS015840305;CS-W005784;AS-12152

Chemical Property of (R)-1-Chloro-2-propanol

Chemical Property:

• Boiling Point: 126.499 °C at 760 mmHg
• PKA: 14.09±0.20(Predicted)
• Flash Point: 54.541 °C
• PSA: 20.23000
• Density: 1.083 g/cm³
• LogP: 0.60600
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 94.0185425
• Heavy Atom Count: 5
• Complexity: 22.9

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-Chloro-2-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CCl)O
• Isomeric SMILES: C[C@H](CCl)O

Technology Process of (R)-1-Chloro-2-propanol

There total 10 articles about (R)-1-Chloro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

methanol (67-56-1) + (S)-Propylene oxide (16088-62-3) → (R)-1-methoxy-2-propanol (4984-22-9) + (2R)-2-methoxypropan-1-ol (6131-59-5) + (R)-(-)-1-chloro-2-propanol (19141-39-0)

Guidance literature:

With Cu(L-Asp)(1,2-bis(4-pyridyl)ethylene)0.5(H₂O)0.5(MeOH)0.5; at 25 ℃;

DOI:10.1039/b718443c

Reference yield: 45.0%

methyloxirane (75-56-9,16033-71-9) → 1-chloro-2(S)-hydroxypropane (37493-16-6) + (R)-(-)-1-chloro-2-propanol (19141-39-0) + (R)-propylene oxide (15448-47-2) + (S)-Propylene oxide (16088-62-3)

Guidance literature:

With hydrogenchloride; (R,R)-[Co(salen)]*GaCl₃; In diethyl ether; at 0 - 4 ℃; for 1h;

DOI:10.1016/j.jorganchem.2005.12.044

Reference yield:

propene (187737-37-7,13987-01-4,15220-87-8,9003-07-0,676-63-1,25085-53-4) → (S)-2-chloropropan-1-ol (19210-21-0) + 1-chloro-2(S)-hydroxypropane (37493-16-6) + (R)-(-)-1-chloro-2-propanol (19141-39-0) + (R)-(-)-2-chloro-propan-1-ol (37493-14-4)

Guidance literature:

With copper dichloride; [Pd(CH₃CN)2{(S)-BINAP}](BF₄)2; 1,3-diacetyl acetone; In tetrahydrofuran; at 25 ℃; Further Variations:; Catalysts; Solvents; Reagents; Product distribution;

DOI:10.1016/S0022-328X(00)00070-X

upstream raw materials:

(R)-propylene oxide

chloroacetone

1-Chloro-2-propanol

propene

Downstream raw materials:

C₁₈H₁₆ClN₅O₂

(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxypropyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

(R)-methyl 2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoate

Refernces

• 1、 Ingleson, Michael J.,Barrio, Jorge Perez,Bacsa, John,Dickinson, Calum,Park, Hyunsoo,Rosseinsky, Matthew J.. "Generation of a solid Bronsted acid site in a chiral framework". . p. 1287 - 1289. Retrieved 2008/12/21.
• 2、 Thakur, Santosh Singh,Li, Wenji,Kim, Seong-Jin,Kim, Geon-Joong. "Highly reactive and enantioselective kinetic resolution of terminal epoxides with H2O and HCl catalyzed by new chiral (salen)Co complex linked with Al". . p. 2263 - 2266. Retrieved 2007/10/03.