Meclofenoxate hydrochloride

Base Information

• Chemical Name: Meclofenoxate hydrochloride
• CAS No.: 3685-84-5
• Deprecated CAS: 1334-20-9
• Molecular Formula: C12H17Cl2NO3
• Molecular Weight: 294.178
• Hs Code.: 2922509090
• European Community (EC) Number: 222-975-3
• NSC Number: 758420,113619,4268
• UNII: 5BK3070BDY
• DSSTox Substance ID: DTXSID8045141
• Wikidata: Q27261792
• ChEMBL ID: CHEMBL1256131
• Mol file: 3685-84-5.mol

Synonyms:Atsefen;Centrophenoxine;Cerutil;Cetrexin;Helfergin;Meclofenoxate;Meclofenoxate Hydrochloride

Chemical Property of Meclofenoxate hydrochloride

Chemical Property:

• Appearance/Colour: white crystal powder
• Vapor Pressure: 5.95E-05mmHg at 25°C
• Melting Point: 133-135 °C
• Refractive Index: 1.6140 (estimate)
• Boiling Point: 345.9 °C at 760 mmHg
• Flash Point: 163 °C
• PSA: 38.77000
• Density: 1.3255 (rough estimate)
• LogP: 2.62560
• Storage Temp.: −20°C
• Solubility.: DMSO (Sparingly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 293.0585488
• Heavy Atom Count: 18
• Complexity: 228

Purity/Quality:

99% ^*data from raw suppliers

MeclofenoxateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCOC(=O)COC1=CC=C(C=C1)Cl.Cl
• Uses: The applications of is Meclofenoxate hydrochloride: Memory decline through aging Dementia and Alzheimer’s (clinically) ?Brain damage or injuries Alcohol or drug abuse symptoms and effects Promote the metabolism of brain Meclofenoxate is a cerebral stimulant. Also, Meclofenoxate is used as plant growth regulator. Plant growth regulator. Cerebral stimulant;Acetylcholine precursor

Technology Process of Meclofenoxate hydrochloride

There total 2 articles about Meclofenoxate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(N,N-dimethylamino)ethanol (108-01-0) + 4-chlorophenyloxyacetyl chloride (4122-68-3) → meclofenoxate hydrochloride (3685-84-5)

Guidance literature:

In chloroform;

DOI:10.1039/c8nj01239c

Reference yield:

4-Chlorophenoxyacetic acid (122-88-3) → meclofenoxate hydrochloride (3685-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: benzene / Behandeln des Reaktionsprodukts mit Chlorwasserstoff in Aether und Aceton

With thionyl chloride; benzene;

Reference yield: 78.0%

meclofenoxate hydrochloride (3685-84-5) → meclofenoxate (51-68-3)

Guidance literature:

With triethylamine; In chloroform;

DOI:10.1039/c8nj01239c

upstream raw materials:

2-(N,N-dimethylamino)ethanol

4-chlorophenyloxyacetyl chloride

4-Chlorophenoxyacetic acid

Downstream raw materials:

2-(N,N-dimethylamino)ethanol

4-Chlorophenoxyacetic acid

2-(N,N-dimethylamino)ethanol hydrochloride

meclofenoxate

Refernces

• 1、 Syguda, Anna,Gielnik, Anna,Borkowski, Andrzej,Wo?niak-Karczewska, Marta,Parus, Anna,Piechalak, Aneta,Olejnik, Anna,Marecik, Roman,?awniczak, ?ukasz,Chrzanowski, ?ukasz. "Esterquat herbicidal ionic liquids (HILs) with two different herbicides: Evaluation of activity and phytotoxicity". supporting information. p. 9819 - 9827. Retrieved 2018/06/18.