Propanedioic acid, dihydrazide

Base Information

• Chemical Name: Propanedioic acid, dihydrazide
• CAS No.: 3815-86-9
• Molecular Formula: C3H8N4O2
• Molecular Weight: 132.122
• Hs Code.: 2928000090
• European Community (EC) Number: 670-404-5
• NSC Number: 649
• UNII: 8B7G9U6NJL
• DSSTox Substance ID: DTXSID00191543
• Nikkaji Number: J36.621H
• Wikidata: Q72488129
• Mol file: 3815-86-9.mol

Synonyms:Malonic acid dihydrazide;3815-86-9;Malonohydrazide;propanedihydrazide;Propanedioic acid, dihydrazide;Malonic dihydrazide;Malonhydrazide;Malonyl dihydrazide;Malonyl hydrazide;Malonic acid, dihydrazide;Malonic acid hydrazide;Malonoyldihydrazine;Propanedioyl dihydrazide;Malondihydrazide;C3H8N4O2;AI3-62532;BRN 1072337;8B7G9U6NJL;NSC-649;3-02-00-01636 (Beilstein Handbook Reference);Malonohydrazide #;Malonoyl dihydrazine;malonic acid dihydrazone;UNII-8B7G9U6NJL;(3-Bromophenyl)succinicacid;SCHEMBL220535;NSC649;PSIKPHJLTVSQFO-UHFFFAOYSA-;DTXSID00191543;NSC 649;Propanedioic acid, 1,3-dihydrazide;BBL005139;MFCD00041268;STK408130;AKOS000267172;CS-W013419;SB85904;LS-88807;MS-20154;FT-0628126;M3206;E77585;A824031;J-521670

Chemical Property of Propanedioic acid, dihydrazide

Chemical Property:

• Vapor Pressure: 2.59E-12mmHg at 25°C
• Melting Point: 152-154°C
• Refractive Index: 1.534
• Boiling Point: 554 °C at 760 mmHg
• PKA: 11.88±0.35(Predicted)
• Flash Point: 288.8 °C
• PSA: 110.24000
• Density: 1.358 g/cm³
• LogP: -0.46130
• XLogP3: -2.5
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 132.06472551
• Heavy Atom Count: 9
• Complexity: 109

Purity/Quality:

99% ^*data from raw suppliers

Malonic Acid Dihydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)NN)C(=O)NN

Technology Process of Propanedioic acid, dihydrazide

There total 5 articles about Propanedioic acid, dihydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(1-hydroxyethylidene)malonic acid diethyl ester (31575-84-5) → malonic acid dihydrazide (3815-86-9) + diethyl malonate (105-53-3)

Guidance literature:

With hydrazine; In ethanol; for 3h; Heating;

DOI:10.1016/S0040-4020(02)00306-X

Reference yield: 45.0%

diethyl acetylmalonate (570-08-1) → malonic acid dihydrazide (3815-86-9) + diethyl malonate (105-53-3)

Guidance literature:

With hydrazine; In ethanol; for 3h; Heating;

DOI:10.1081/SCC-120015395

Reference yield: 34.0%

diethyl malonate (105-53-3) → malonic acid dihydrazide (3815-86-9) + ethyl 3-hydrazino-3-oxopropanoate (30866-24-1)

Guidance literature:

With hydrazine hydrate; In ethanol;

DOI:10.1007/s10593-010-0527-9

upstream raw materials:

ethanol

diethyl malonate

(1-hydroxyethylidene)malonic acid diethyl ester

diethyl acetylmalonate

Downstream raw materials:

malonic acid bis-(2-chloro-benzylidenehydrazide)

Malonic acid di-2-benzalhydrazide

malonic acid bis-(3-chloro-benzylidenehydrazide)

hydrazine

Refernces

• 1、 Metwally, Saoud A.M.,Moneim, Maisa I. Abdel,Elossely, Yasser A.,Awad, Radwa I.,Abou-Hadeed, Khaled. "Synthesis and crystal structure of some 3,5-pyrazolidinediones". . p. 426 - 437. Retrieved 2014/05/06.
• 2、 Jung, Jae C.,Watkins, E Blake,Avery, Mitchell A.. "Efficient synthesis of 4-ethoxycarbonyl pyrazolin-5-one derivatives". . p. 3767 - 3777. Retrieved 2007/10/03.