Ethyl malonyl hydrazide

Base Information

• Chemical Name: Ethyl malonyl hydrazide
• CAS No.: 30866-24-1
• Molecular Formula: C5H10 N2 O3
• Molecular Weight: 146.146
• Hs Code.: 2928000090
• Mol file: 30866-24-1.mol

Synonyms:Propanedioicacid, monoethyl ester, hydrazide (9CI); (Ethoxycarbonyl)acetic acid hydrazide;2-(Ethoxycarbonyl)acetohydrazide; Ethoxycarbonyl acetohydrazide;Ethoxycarbonylacetylhydrazine; Ethyl 3-hydrazino-3-oxopropanoate; Ethyl3-hydrazino-3-oxopropionate; Ethyl hydrazinocarbonylacetate; NSC 75205

Chemical Property of Ethyl malonyl hydrazide

Chemical Property:

• Vapor Pressure: 0.000309mmHg at 25°C
• Melting Point: 72-75 ºC
• Boiling Point: 320.9°C at 760 mmHg
• PKA: 12.02±0.35(Predicted)
• Flash Point: 147.8°C
• PSA: 81.42000
• Density: 1.176g/cm³
• LogP: 0.02070
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 3-hydrazino-3-oxopropionate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Ethyl 3-hydrazino-3-oxopropionate may be used in the following studies:As starting reagent in the step-wise construction of complex pyrrole-pyrazole system., Synthesis of 4,5-dihydro-1H-pyrazoles, via reaction with 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones, using conventional thermal heating method and a microwave-assisted method.Synthesis of pyrazolopyridazine.

Technology Process of Ethyl malonyl hydrazide

There total 5 articles about Ethyl malonyl hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

diethyl malonate (105-53-3) → ethyl 3-hydrazino-3-oxopropanoate (30866-24-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃;

Reference yield: 34.0%

diethyl malonate (105-53-3) → malonic acid dihydrazide (3815-86-9) + ethyl 3-hydrazino-3-oxopropanoate (30866-24-1)

Guidance literature:

With hydrazine hydrate; In ethanol;

DOI:10.1007/s10593-010-0527-9

Reference yield: 31.0%

ethyl 3-amino-2-ethoxycarbonyl-2-butenoate (137786-67-5) → ethyl 3-hydrazino-3-oxopropanoate (30866-24-1) + diethyl malonate (105-53-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Heating;

DOI:10.1081/SCC-120015395

upstream raw materials:

ethanol

diethyl malonate

ethyl 3-amino-2-ethoxycarbonyl-2-butenoate

Cyanoacetohydrazide

Downstream raw materials:

[1-(2,4-Dichloro-phenyl)-meth-(E)-ylidene-hydrazinocarbonyl]-acetic acid ethyl ester

(Z)-3-(2,4-Dichloro-phenyl)-2-[1-(2,4-dichloro-phenyl)-meth-(E)-ylidene-hydrazinocarbonyl]-acrylic acid ethyl ester

(6-phenyl-4H-2,3,5,10b-tetraazabenzo[e]azulen-1-yl)acetic acid ethyl ester

1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Refernces

• 1、 Tang, Yongxing,Dharavath, Srinivas,Imler, Gregory H.,Parrish, Damon A.,Shreeve, Jean'ne M.. "Nitramino- and Dinitromethyl-Substituted 1,2,4-Triazole Derivatives as High-Performance Energetic Materials". . p. 9185 - 9191. Retrieved 2017.
• 2、 Abdel-Aziz, Hatem A.,Elsaman, Tilal,Al-Dhfyan, Abdullah,Attia, Mohamed I.,Al-Rashood, Khalid A.,Al-Obaid, Abdul-Rahman M.. "Synthesis and anticancer potential of certain novel 2-oxo-N'-(2-oxoindolin- 3-ylidene)-2H-chromene-3-carbohydrazides". . p. 358 - 363. Retrieved 2013.
• 3、 -. "METALLOENZYME INHIBITOR COMPOUNDS". Paragraph 1292; 1293; 1294; 1295. . Retrieved 2018/07/29.