phenyl p-tolylmethyl ketone O-methyloxime

Base Information

• Chemical Name: phenyl p-tolylmethyl ketone O-methyloxime
• CAS No.: 111630-13-8
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.317
• Mol file: 111630-13-8.mol

Synonyms:phenyl p-tolylmethyl ketone O-methyloxime

Chemical Property of phenyl p-tolylmethyl ketone O-methyloxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phenyl p-tolylmethyl ketone O-methyloxime

There total 2 articles about phenyl p-tolylmethyl ketone O-methyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methylphenylacetyl chloride (35675-44-6) → phenyl p-tolylmethyl ketone O-methyloxime (111630-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃

2: pyridine / Ambient temperature

With pyridine; aluminium trichloride;

DOI:10.1021/jm00066a002

Reference yield:

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → phenyl p-tolylmethyl ketone O-methyloxime (111630-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃

2: pyridine / Ambient temperature

With pyridine; aluminium trichloride;

DOI:10.1021/jm00066a002

Reference yield: 64.0%

(1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) + phenyl p-tolylmethyl ketone O-methyloxime (111630-13-8) → (S)-2-(4-methylphenyl)-1-phenylethylamine (30339-30-1,42291-04-3)

Guidance literature:

With borane; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0040-4039(00)80059-3

upstream raw materials:

4-methylphenylacetyl chloride

benzene

Downstream raw materials:

(S)-2-(4-methylphenyl)-1-phenylethylamine

(R)-1-phenyl-2-(p-tolyl)ethylamine

1-phenyl-2-(p-tolyl)ethylamine

(2,2-Diethoxy-ethyl)-(1-phenyl-2-p-tolyl-ethyl)-amine

Refernces