(S)-1-PHENYL-2-(P-TOLYL)ETHYLAMINE

Base Information

• Chemical Name: (S)-1-PHENYL-2-(P-TOLYL)ETHYLAMINE
• CAS No.: 30275-30-0
• Molecular Formula: C15H17N
• Molecular Weight: 211.307
• Hs Code.: 2921499090
• Mol file: 30275-30-0.mol

Synonyms:(S)-1-Phenyl-2-(p-tolyl)ethylamine;1-Phenyl-2-(p-tolyl)ethylamine;1-Phenyl-2-(4-tolyl)ethylamine;1-Phenyl-2-(4'-tolyl)ethylamine;1-Phenyl-2-(p-tolyl)ethylamine;a-Phenyl-b-p-tolylethylamine;

Chemical Property of (S)-1-PHENYL-2-(P-TOLYL)ETHYLAMINE

Chemical Property:

• Vapor Pressure: 0.000375mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 317.8 °C at 760 mmHg
• PKA: 8.89±0.10(Predicted)
• Flash Point: 145.8 °C
• PSA: 26.02000
• Density: 1.037 g/cm³
• LogP: 3.93780

Purity/Quality:

98% ^*data from raw suppliers

1-Phenyl-2-(p-tolyl)ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Phenyl-2-(p-tolyl)ethylamine is an intermediate used to prepare γ-nitroaldehydes with quaternary stereogenic centers. (S)-1-Phenyl-2-(p-tolyl)ethylamine is used as a reagent in the synthesis of optical active pyrethroids compound which can be used as an insecticide for mosquitoes, flies or cockroaches. It is also used in the synthesis of 2,2''-Dihydroxybenzil which acts as a stereodynamic probe for primary amines controlled by steric strain.

Technology Process of (S)-1-PHENYL-2-(P-TOLYL)ETHYLAMINE

There total 12 articles about (S)-1-PHENYL-2-(P-TOLYL)ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 2-phenyl-3-para-tolylpropanamide + 1-phenyl-2-(p-tolyl)ethylamine (30275-30-0,42291-04-3)

Guidance literature:

Reference yield: 91.0%

→ 1-phenyl-2-(p-tolyl)ethylamine (30275-30-0,42291-04-3)

Guidance literature:

Reference yield: 87.0%

1-phenyl-2-p-tolylethanone (2430-99-1) → 1-phenyl-2-(p-tolyl)ethylamine (30275-30-0,42291-04-3)

Guidance literature:

With nickel(II) tetrafluoroborate hexahydrate; ammonia; hydrogen; bis(2-diphenylphosphinoethyl)phenylphosphine; In 2,2,2-trifluoroethanol; at 120 ℃; for 24h; chemoselective reaction;

DOI:10.1039/d0sc01084g

upstream raw materials:

4-methylstilbene

phenyl p-tolylmethyl ketone O-methyloxime

4-methylphenylacetyl chloride

benzene

Downstream raw materials:

(1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,5,6,7,8,9,10,10a-dodecahydro-phenanthrene-1-carboxylic acid (1-phenyl-2-p-tolyl-ethyl)-amide

(2,2-Diethoxy-ethyl)-(1-phenyl-2-p-tolyl-ethyl)-amine

(S)-2-(4-methylphenyl)-1-phenylethylamine

(R)-1-phenyl-2-(p-tolyl)ethylamine

Refernces

• 1、 Liu, Guoqing,Walsh, Patrick J.,Mao, Jianyou. "Alkaline-metal-catalyzed one-pot aminobenzylation of aldehydes with toluenes". supporting information. p. 8514 - 8518. Retrieved 2019/10/11.
• 2、 -. "Process for producing optically active 3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic acid, and salt thereof". . . Retrieved 2008/06/13.