Cyromazine

Base Information

• Chemical Name: Cyromazine
• CAS No.: 66215-27-8
• Molecular Formula: C6H10N6
• Molecular Weight: 166.186
• Hs Code.: 29336990
• European Community (EC) Number: 266-257-8
• NSC Number: 759268
• UNII: CA49Y29RA9
• DSSTox Substance ID: DTXSID6023999
• Nikkaji Number: J18.757G
• Wikipedia: Cyromazine
• Wikidata: Q412423
• NCI Thesaurus Code: C76870
• Metabolomics Workbench ID: 44089
• ChEMBL ID: CHEMBL1231107
• Mol file: 66215-27-8.mol

Synonyms:2-cyclopropylamino-4,6-diamino-s-triazine;CGA 72662;CGA-72662;cyromazin;cyromazine;cyromazine dihydrochloride;Larvadex;N-cyclopropyl-1,3,5-triazine-2,4,6-triamine;N-cyclopropylmelamine;Neporex;Vetrazin

Chemical Property of Cyromazine

Chemical Property:

• Appearance/Colour: Colorless crystal
• Vapor Pressure: 4.5 x l0-7 Pa (25 °C)
• Melting Point: 223-227 °C(lit.)
• Refractive Index: 1.8300 (estimate)
• Boiling Point: 480.7 °C at 760 mmHg
• PKA: 5.2 (base)
• Flash Point: 244.5 °C
• PSA: 102.74000
• Density: 1.622 g/cm³
• LogP: 0.84570
• Storage Temp.: 0-6°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: 13 g l-1 (pH 7.1,25 °C)
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 166.09669434
• Heavy Atom Count: 12
• Complexity: 148

Purity/Quality:

99% ^*data from raw suppliers

Cyromazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Pesticides -> Other Insecticides
• Canonical SMILES: C1CC1NC2=NC(=NC(=N2)N)N
• Description: Cyromazine is a triazine insect growth regulator that can be used as an insecticide and an acarcide. It is a kind of cyclopropylderivative of melamine, and also belongs to the family of aminotriazines which are compound consisting of an amino group attached to a triazine ring. It has specific activity against dipterous larvae, and has been approved by FDA for being applied to livestock. It is not a kind of cholinesterase inhibitor, and taking effect through affecting the nervous system of the immature larval stage of the insects.
• Uses: Cypromazine is a high-efficiency and low-toxicity insecticide. It is mainly used to control leafminer pests, has a good control effect on Liriomyza, and can also be used to control flies.

Technology Process of Cyromazine

There total 5 articles about Cyromazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.37%

2-Chloro-4,6-diamino-1,3,5-triazine (3397-62-4) + Cyclopropylamine (765-30-0) → cyromazine (66215-27-8)

Guidance literature:

With sodium hydroxide; at 70 - 85 ℃; for 6h; pH=9.5; pH-value; Temperature;

Reference yield: 93.5%

2,4-dichloro-6-cyclopropylamino-1,3,5-triazine (32889-45-5) → cyromazine (66215-27-8)

Guidance literature:

With ammonia; In water; toluene; at 120 ℃; for 10h; under 4500.45 Torr;

Reference yield:

6-chloro-N-cyclopropyl-[1,3,5]triazine-2,4-diamine (35516-73-5) → cyromazine (66215-27-8)

Guidance literature:

With ammonia; In 1,4-dioxane; water;

upstream raw materials:

1,4-dioxane

6-chloro-N-cyclopropyl-[1,3,5]triazine-2,4-diamine

2-Chloro-4,6-diamino-1,3,5-triazine

Cyclopropylamine

Refernces

• 1、 -. "Synthesis method of cyromazine active compound with high yield". Paragraph 0040-0063. . Retrieved 2021/05/29.
• 2、 -. "A cyclopropanecarboxylic ammonia qin preparation method (by machine translation)". Paragraph 0033; 0034; 0037; 0041. . Retrieved 2018/08/04.