Tetraethylammonium chloride

Base Information

• Chemical Name: Tetraethylammonium chloride
• CAS No.: 56-34-8
• Molecular Formula: C8H20ClN
• Molecular Weight: 165.706
• Hs Code.: 29239000
• European Community (EC) Number: 200-267-5
• UNII: 8B82Z83XNN
• DSSTox Substance ID: DTXSID6041137
• Wikipedia: Tetraethylammonium_chloride
• Wikidata: Q7706336
• Metabolomics Workbench ID: 133999
• ChEMBL ID: CHEMBL434435
• Mol file: 56-34-8.mol

Synonyms:Bromide, Tetraethylammonium;Chloride, Tetraethylammonium;Hydroxide, Tetraethylammonium;Iodide, Tetraethylammonium;Ion, Tetraethylammonium;Tetraethylammonium;Tetraethylammonium Bromide;Tetraethylammonium Chloride;Tetraethylammonium Hydroxide;Tetraethylammonium Iodide;Tetraethylammonium Ion

Chemical Property of Tetraethylammonium chloride

Chemical Property:

• Appearance/Colour: white crystalline powder
• Melting Point: 39 °C
• Refractive Index: 1.5480 (estimate)
• Boiling Point: 273.32°C (rough estimate)
• PSA: 0.00000
• Density: 1.08 g/cm³
• LogP: -1.11320
• Storage Temp.: Store at RT
• Sensitive.: Hygroscopic
• Solubility.: methanol: 0.1 g/mL, clear, colorless
• Water Solubility.: Soluble in water, ethanol, chloroform, or acetone
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 165.1284273
• Heavy Atom Count: 10
• Complexity: 47.5

Purity/Quality:

99% ^*data from raw suppliers

Tetraethylammonium chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Quaternary Amines
• Canonical SMILES: CC[N+](CC)(CC)CC.[Cl-]
• Uses: Medicine (nerve-blocking agent). Tetraethylammonium Chloride can be used as a source of tetraethylammonium ions for various pharmaceutical studies and has the ability to block K+ channels in various tissues. Tetraethylammonium Chloride can also block the transmission of nervous impulses across autonomic ganglions. Tetraethylammonium chloride (TEAC) has been used:used for inhibition of peroxynitrite induced relaxation in rat aorta ringsas a pharmacological blocker of K+ current and Ca2+ induced K+ current in antennal lobe neuronsfor the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties

Technology Process of Tetraethylammonium chloride

There total 22 articles about Tetraethylammonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

cis-(3,5-bis(ethoxycarbonyl)-4,6-diphenyl-2H-pyran-2-ylidene)dichloro(triphenylphosphine)platinum + tetraethylammonium iodide (68-05-3) → (Pt(CC(CO2C2H5)C(C6H5)C(CO2C2H5)C(C6H5)O)(P(C6H5)3)I2) + tetraethylammonium chloride (56-34-8)

Guidance literature:

In methanol; under N2 atm. to soln. NEt4I in CH3OH added (Pt(CC(CO2Et)=C(Ph)C(CO2Et)=C(Ph)O)(PPh3)Cl2) and stirred at room temp. for 24 h; solid filtered off, washed with methanol and dried; elem. anal.;

Reference yield: 63.0%

(tetraethylammonium)(CpFe(carbonyl)2) (57812-16-5) + (η6-p-(CH3O2C)ClC6H4)chromium tricarbonyl (12241-54-2) → cyclopentadienyl iron(II) dicarbonyl dimer (38117-54-3) + (η6-p-(CH3O2C)CpFe(carbonyl)2C6H4)chromium tricarbonyl (114636-10-1) + tetraethylammonium chloride (56-34-8)

Guidance literature:

In tetrahydrofuran; Dissolution of reactants in THF (protective gas), swirling.; Filtn., evapn., extn. with Et2O followed by extn. with hot toluene, filtn., concg., refrigeration at -20°C, elem. anal.;

Reference yield: 60.0%

(tetraethylammonium)(CpFe(carbonyl)2) (57812-16-5) + (η6-m-(CF3)ClC6H4)chromium tricarbonyl (114636-07-6) → cyclopentadienyl iron(II) dicarbonyl dimer (38117-54-3) + (η6-m-(CF3)(CpFe(carbonyl)2)C6H4))chromium tricarbonyl (114636-09-8) + tetraethylammonium chloride (56-34-8)

Guidance literature:

In tetrahydrofuran; Dissolution of reactants in THF (protective gas), swirling.; Filtn., evapn., extn. with Et2O followed by extn. with hot toluene, filtn., concg., refrigeration at -20°C, elem. anal.;

upstream raw materials:

diethyl sulfate

triethylamine

tri-tert-butoxy-chloro-silane

tetraethylammoniumcyanide

Downstream raw materials:

C₈H₂₀N⁽¹⁺⁾*C₆Cl₃F₅P^(1-)

tetraethylammoniumcyanide

1-(3,3-dimethyl-6-nitro-2,3-dihydro-indol-1-yl)-ethanone

2-bromophenyl 1-[2'-(2''-bromophenyl)ethyl]-4-iodopyrrole-2-carboxylate

Refernces

• 1、 Zheng, Zhuoqun,Wu, Tinghua,Zhou, Xiaoping. "The synthesis of quaternary ammonium salts from ammonium salts and dialkyl carbonate". . p. 1864 - 1865. Retrieved 2008/03/14.
• 2、 Lee, Dong Hoon,Lee, Kwan Hee,Hong, Jong-In. "An azophenol-based chromogenic anion sensor". . p. 5 - 7. Retrieved 2007/10/03.