2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide

Base Information

• Chemical Name: 2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide
• CAS No.: 1204192-94-8
• Molecular Formula: C₁₇H₁₈N₂O₂S₂
• Molecular Weight: 346.474
• Mol file: 1204192-94-8.mol

Synonyms:2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide

Chemical Property of 2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide

There total 2 articles about 2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(4-hydrazinylphenyl)-N-methylethane-1-sulfonamide hydrochloride (42381-27-1) + phenylmercaptoacetaldehyde dimethyl acetal (99172-76-6) → 2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide (1204192-94-8)

Guidance literature:

2-(4-hydrazinylphenyl)-N-methylethane-1-sulfonamide hydrochloride; With sulfuric acid; In methanol; water; at 20 ℃; for 0.5h;

phenylmercaptoacetaldehyde dimethyl acetal; In methanol; water; at 20 ℃;

In methanol; ethanol; water;

DOI:10.2174/1570178614666170907144641

Reference yield:

thiophenol (108-98-5) → 2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide (1204192-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 1.25 h / 25 - 30 °C

1.2: 1 h / 25 - 30 °C

2.1: sulfuric acid / methanol; water / 0.5 h / 20 °C

2.2: 20 °C

2.3: polyphosphoric acid

With sulfuric acid; potassium hydroxide; In methanol; water;

DOI:10.2174/1570178614666170907144641

Reference yield: 95.0%

2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide (1204192-94-8) → N-Methyl-1H-indole-5-ethanesulphonamide (98623-50-8)

Guidance literature:

With hydrogen; at 40 - 45 ℃; for 10h; under 2250.23 - 3000.3 Torr; Autoclave;

DOI:10.2174/1570178614666170907144641

upstream raw materials:

2-(4-hydrazinylphenyl)-N-methylethane-1-sulfonamide hydrochloride

phenylmercaptoacetaldehyde dimethyl acetal

thiophenol

Downstream raw materials:

N-Methyl-1H-indole-5-ethanesulphonamide

naratriptan

N-methyl-2-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl)ethane-1-sulfonamide

Refernces

• 1、 -. "PROCESS FOR PREPARING INDOLE DERIVATIVES". Page/Page column 18. . Retrieved 2010/04/03.