Maleic Acid

Base Information

• Chemical Name: Maleic Acid
• CAS No.: 26099-09-2
• Deprecated CAS: 1975169-66-4
• Molecular Formula: C₄H₄O₄
• Molecular Weight: 116.073
• European Community (EC) Number: 203-742-5,607-861-7
• ICSC Number: 1186
• NSC Number: 25940
• UN Number: 2215,3261
• UNII: 91XW058U2C
• DSSTox Substance ID: DTXSID8021517
• Nikkaji Number: J2.446E
• Wikipedia: Maleic_acid
• Wikidata: Q42038
• NCI Thesaurus Code: C25951
• RXCUI: 1426330
• Pharos Ligand ID: G85TY71W8BTL
• Metabolomics Workbench ID: 37118
• ChEMBL ID: CHEMBL539648
• Mol file: 26099-09-2.mol

Synonyms:hydrogen maleate;maleate;maleic acid;maleic acid, ammonium salt;maleic acid, calcium salt;maleic acid, dipotassium salt;maleic acid, disodium salt;maleic acid, iron salt;maleic acid, monoammonium salt;maleic acid, monocopper (2+) salt;maleic acid, monosodium salt;maleic acid, neodymium salt;maleic acid, potassium salt;maleic acid, sodium salt;sodium maleate

Chemical Property of Maleic Acid

Chemical Property:

• Appearance/Colour: orange transparent liquid
• Flash Point: 95 °C
• PSA: 74.60000
• Density: 1.18 (48% aq.)
• LogP: -0.28820
• Storage Temp.: 2-8°C
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 116.01095860
• Heavy Atom Count: 8
• Complexity: 119
• Transport DOT Label: Corrosive

Purity/Quality:

99% ^*data from raw suppliers

PolymaleicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xi
• Statements: 36-43-36/37/38
• Safety Statements: 24/25-28-36/37/39-36/37-26

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: UVCB,Other Classes -> Organic Acids
• Canonical SMILES: C(=CC(=O)O)C(=O)O
• Isomeric SMILES: C(=C\C(=O)O)\C(=O)O
• Recent ClinicalTrials: Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.
• Inhalation Risk: Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
• Effects of Short Term Exposure: The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract.
• Effects of Long Term Exposure: Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.
• Description: Polymaleic acid is the homopolymer of maleic acid. It is very stable in presence of chlorine and other oxidizing biocides. It has good scale inhibition and high temperature resistance properties. Therefore, it can be used in the water desalination plants. It is also an excellent calcium carbonate antiscalant upon high temperature and in the high alkaline cooling water systems. In addition, it can be used in combination with zinc salts as a corrosion inhibitor. It can also be used as concrete additive and for crude oil evaporation. It can be manufactured through the polymerization of maleic anhydride I an aromatic hydrocarbon upon 60° to 200° C.
• Uses: Food additive

Technology Process of Maleic Acid

There total 615 articles about Maleic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) → D-Malic acid (636-61-3,78644-42-5) + (2S)-chlorobutanedioic acid (4198-33-8,617-41-4) + 2-butenedioic acid (6915-18-0,26099-09-2)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at -15 - 0 ℃; for 8h;

Reference yield: 79.0%

(R)-4,4,4-trichloro-3-hydroxybutanoic acid (80513-23-1) → D-Malic acid (636-61-3,78644-42-5) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 24h;

DOI:10.1021/ja00365a030

Reference yield: 0.04%

maleic acid (110-16-7,26099-09-2) → tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 4-butanolide (96-48-0) + Butane-1,4-diol (110-63-4) + 4-hydroxybutanoic acid (591-81-1) + malic acid (617-48-1,78644-42-5) + succinic acid (110-15-6) + terephthalic acid (100-21-0) + acetic acid (64-19-7,77671-22-8) + propionic acid (802294-64-0,79-09-4) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2)

Guidance literature:

With hydrogen; 0.5percent Pd/0.2percent Re on Rutile TiO₂; at 110 ℃; for 170 - 1009h; Product distribution / selectivity;

upstream raw materials:

tetrahydrofuran

piperidine

pyridine

malonic acid

Downstream raw materials:

4-methoxycarbonyl-pyrazoline-3-carboxylic acid methyl ester

3,4-dimethyl-6-(2-methyl-propenyl)-cyclohex-4-ene-1,2-dicarboxylic acid

endo, cis-7-oxabicyclo<2.2.1>hept-5-ene-2,3-dicarboxylic acid

7-Oxa-bicyclo-<2.2.1>-hept-5-en-2,3-exo,exo-dicarbonsaeure

Refernces

• 1、 Cao, Di,Chen, Fan,Cheng, Hao,Huang, Cong,Li, Zhi-Ling,Liang, Bin,Nan, Jun,Sun, Kai,Wang, Ai-Jie. "Ordered mesoporous carbon as an efficient heterogeneous catalyst to activate peroxydisulfate for degradation of sulfadiazine". supporting information. . Retrieved 2022/01/26.
• 2、 -. "Catalyst for catalytic oxidation of furfural to prepare maleic acid and application thereof". Page/Page column 10-12. . Retrieved 2022/02/10.