(R)-1-Cbz-3-Aminopyrrolidine hydrochloride

Base Information

• Chemical Name: (R)-1-Cbz-3-Aminopyrrolidine hydrochloride
• CAS No.: 870621-17-3
• Molecular Formula: C12H16N2O2^.HCl
• Molecular Weight: 256.732
• Hs Code.: 2933990090
• Mol file: 870621-17-3.mol

Synonyms:1-Pyrrolidinecarboxylicacid, 3-amino-, phenylmethyl ester, monohydrochloride, (3R)- (9CI);

Chemical Property of (R)-1-Cbz-3-Aminopyrrolidine hydrochloride

Chemical Property:

• Boiling Point: 381.7 °C at 760 mmHg
• Flash Point: 184.6 °C
• PSA: 55.56000
• LogP: 2.79640
• Storage Temp.: Room temperature.
• Water Solubility.: Soluble in water

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-Amino-1-carbobenzoxypyrrolidine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-Cbz-3-Aminopyrrolidine hydrochloride

There total 1 articles about (R)-1-Cbz-3-Aminopyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyl (3R)-3-[(tert-butoxycarbonyl)amino]pyrrolidine-1-carboxylate (122536-75-8) → (R)-Cbz-3-aminopyrrolidine hydrochloride (870621-17-3)

Guidance literature:

With hydrogenchloride; acetic acid; In methoxybenzene; for 0.333333h;

Reference yield: 93.8%

(R)-Cbz-3-aminopyrrolidine hydrochloride (870621-17-3) + 5-bromovaleroyl chloride (4509-90-4) → C17H23BrN2O3

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

1-t-butyloxycarbonylindole-6-carboxylic acid (208772-42-3) + (R)-Cbz-3-aminopyrrolidine hydrochloride (870621-17-3) → 1-Cbz-3R-[[1-(t-butyloxycarbonyl)indol-6-yl]-carbonyl]aminopyrrolidine (400653-32-9)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 24h;

upstream raw materials:

Benzyl (3R)-3-[(tert-butoxycarbonyl)amino]pyrrolidine-1-carboxylate

Downstream raw materials:

1-Cbz-3R-[[1-(t-butyloxycarbonyl)indol-6-yl]-carbonyl]aminopyrrolidine

Refernces