(R)-(-)-2-Amino-1-propanol

Base Information

• Chemical Name: (R)-(-)-2-Amino-1-propanol
• CAS No.: 35320-23-1
• Molecular Formula: C3H9NO
• Molecular Weight: 75.1106
• Hs Code.: 29221990
• Mol file: 35320-23-1.mol

Synonyms:1-Propanol,2-amino-, (R)-;(-)-2-Amino-1-propanol;(-)-2-Aminopropanol;(-)-Alaninol;(2R)-2-Amino-1-propanol;(R)-(-)-2-Aminopropanol;(R)-2-Aminopropanol;(R)-Alaninol;D-2-Amino-1-propanol;R-(-)-Alaninol;D-Ala-ol;

Chemical Property of (R)-(-)-2-Amino-1-propanol

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Melting Point: 8 °C
• Refractive Index: 1.4490 - 1.4510
• Boiling Point: 212.9 °C at 760 mmHg
• PKA: 12.88±0.10(Predicted)
• Flash Point: 82.6 °C
• PSA: 46.25000
• Density: 1.161 g/cm³
• LogP: 0.02620
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Water Solubility.: SOLUBLE

Purity/Quality:

99% ^*data from raw suppliers

(R)-(-)-2-Amino-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39-45-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-(-)-2-Amino-1-propanol has been used as a derivatizing agent for gossypol during the analysis of gossypol enantiomers in cottonseed by high-performance liquid chromatography.

Technology Process of (R)-(-)-2-Amino-1-propanol

There total 24 articles about (R)-(-)-2-Amino-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

D-Alanine (338-69-2,25191-17-7,18875-37-1) → (R)-2-aminopropan-1-ol (35320-23-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 18.5h; Reflux;

Reference yield: 74.0%

D-alanine ethyl ester hydrochloride (6331-09-5) → (R)-2-aminopropan-1-ol (35320-23-1)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1515/znb-1987-0317

Reference yield: 71.0%

(1R,1'R)-N-benzyl-1-phenyl-1'-methyl-2,2'-dihydroxydiethylamine → (R)-2-aminopropan-1-ol (35320-23-1)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 2h; Heating;

DOI:10.3987/COM-95-7116

upstream raw materials:

2-Azido-1-propanol

AlaOEt

(2R)-2-[(phenylmethyl)amino]-1-propanol

D-alanine methyl ester hydrochloride

Downstream raw materials:

6-methyl-9,10-didehydro-ergoline-8α-carboxylic acid-((R)-β-hydroxy-isopropylamide)

4-methyl-thiazolidine-2-thione

N-(N-Benzyloxycarbonyl-O⁴-benzyl-α-L-aspartyl)-D-alaninol

((R)-4-methyl-4,5-dihydro-oxazol-2-yl)-(5-nitro-thiazol-2-yl)-amine

Refernces

• 1、 -. "Long-chain piperazine ethyl sulfonamide derivative or medicinal salt thereof and preparation method and application of long-chain piperazine ethyl sulfonamide derivative". Paragraph 0016. . Retrieved 2016/10/09.
• 2、 Qu, Yanqing,Zang, Yu,Zhang, Mingyu,Aoki, Toshiki,Teraguchi, Masahiro,Kaneko, Takashi,Ma, Liqun,Jia, Hongge. "Highly efficient helix-sense-selective polymerization of an achiral phenylacetylene having a bulky group". supporting information. p. 1777 - 1779. Retrieved 2016/02/18.