9-Fluorenylmethyl carbamate

Base Information

• Chemical Name: 9-Fluorenylmethyl carbamate
• CAS No.: 84418-43-9
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• Hs Code.: 29242990
• European Community (EC) Number: 805-109-4
• DSSTox Substance ID: DTXSID00352990
• Nikkaji Number: J1.444.583H
• Mol file: 84418-43-9.mol

Synonyms:9-Fluorenylmethyl carbamate;84418-43-9;Fmoc-NH2;9H-fluoren-9-ylmethyl carbamate;9-Fluorenylmethylcarbamate;MFCD00237376;(9h-fluoren-9-yl)methyl carbamate;Fmoc amine;FMOC-amine;N-(9-Fluorenylmethoxycarbonyl)amide;9-Fluorenyl-methyl-carbamate;SCHEMBL113270;SCHEMBL2192202;DTXSID00352990;ZZOKVYOCRSMTSS-UHFFFAOYSA-N;(9H-Fluoren-9-ylmethoxy)carboxamide;AC1112;AKOS015907601;Carbamic Acid 9-Fluorenylmethyl Ester;CS-W016703;AS-17607;SY019088;carbamic acid 9H-fluoren-9-ylmethyl ester;AM20041234;F0689;FT-0641956;9-Fluorenylmethyl carbamate, >=99.0% (HPLC);A840777;J-519510

Chemical Property of 9-Fluorenylmethyl carbamate

Chemical Property:

• Vapor Pressure: 1.24E-08mmHg at 25°C
• Melting Point: 201-204 °C
• Refractive Index: 1.627
• Boiling Point: 459.7 °C at 760 mmHg
• PKA: 13.06±0.50(Predicted)
• Flash Point: 242.3 °C
• PSA: 52.32000
• Density: 1.239 g/cm³
• LogP: 3.59450
• Storage Temp.: 2-8°C
• Solubility.: dioxane: 15 mg/mL, clear, colorless
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 239.094628657
• Heavy Atom Count: 18
• Complexity: 296

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-nh2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36/37/39-27-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N
• Uses: Reagent for the introduction of the Fmoc-group

Technology Process of 9-Fluorenylmethyl carbamate

There total 8 articles about 9-Fluorenylmethyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

9-Fluorenylmethanol (24324-17-2) + sodium isocyanate (917-61-3) → 9-fluorenylmethyl carbamate (84418-43-9)

Guidance literature:

With trifluoroacetic acid; In benzene; for 3h;

DOI:10.1021/jo00153a008

Reference yield:

anisomycin (27958-09-4) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 9-fluorenylmethyl carbamate (84418-43-9)

Guidance literature:

In water; ethyl acetate; acetonitrile;

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) → 9-fluorenylmethyl carbamate (84418-43-9)

Guidance literature:

With ammonia;

DOI:10.1016/S0040-4039(00)79247-1

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

9-Fluorenylmethanol

sodium isocyanate

C₂₃H₁₉NO₄

Downstream raw materials:

1-(9-Fluorenylmethyl)-4-phenylpiperazine

2-<<(R,S)-5-(Fmoc-amino)-10,11-dihydro-5H-dibenzocyclohepten-2-yl>oxy>acetic acid

2-[N-[[(9-fluorenyl)methoxy]carbonyl]amino]-2-(isopropylthio)acetic acid benzyl ester

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpent-4-enoic acid

Refernces

• 1、 Qasmi,Rene,Badet. "An α-aminoglycine derivative suitable for solid phase peptide synthesis using Fmoc strategy". . p. 3861 - 3862. Retrieved 1993.
• 2、 -. "RIBOSOME STRUCTURE AND PROTEIN SYNTHESIS INHIBITORS". . . Retrieved 2008/06/13.