1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine

Base Information

• Chemical Name: 1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine
• CAS No.: 1369303-80-9
• Molecular Formula: C₁₈H₂₁N₃O₂
• Molecular Weight: 311.384
• Mol file: 1369303-80-9.mol

Synonyms:1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine

Chemical Property of 1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine

There total 5 articles about 1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-phenyl-1-piperazine (92-54-6) + 3-(2-Bromoethyl)nitrobenzene (16799-04-5) → 1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine (1369303-80-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1021/acs.jmedchem.7b00738

Reference yield:

2-(3-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone (1369303-78-5) + 2-(4-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone (349410-58-8) → 1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine (1369303-80-9) + 1-[2-(4-nitrophenyl)ethyl]-4-phenylpiperazine (93995-98-3)

Guidance literature:

2-(3-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone; 2-(4-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone; With diborane; In tetrahydrofuran; for 3h; Cooling with ice; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; for 1h; Reflux;

Reference yield:

2-(3-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone (1369303-78-5) → 1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine (1369303-80-9)

Guidance literature:

With diborane; In tetrahydrofuran; at 0 ℃; for 9h; Reflux;

DOI:10.1016/j.bmcl.2012.04.098

upstream raw materials:

2-(3-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone

3-nitro-benzeneacetic acid

2-(4-nitrophenyl)-1-(4-phenylpiperazin-1-yl)ethanone

4-phenyl-1-piperazine

Downstream raw materials:

N-{3-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-2-yl-acetamide

N-{3-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-3-yl-acetamide

N-{3-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-pyridin-4-yl-acetamide

1-phenyl-3-{3-[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-urea

Refernces

• 1、 -. "Quinolone-based compounds, formulations, and uses thereof". Page/Page column 60; 62. . Retrieved 2018/07/02.
• 2、 Sukalovic, Vladimir,Ignjatovic, Djurdjica,Tovilovic, Gordana,Andric, Deana,Shakib, Kaveh,Kostic-Rajacic, Sladjana,Soskic, Vukic. "Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl- acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors". scheme or table. p. 3967 - 3972. Retrieved 2012/07/03.