1-(2-Bromoethyl)-3-nitrobenzene

Base Information

• Chemical Name: 1-(2-Bromoethyl)-3-nitrobenzene
• CAS No.: 16799-04-5
• Molecular Formula: C8H8 Br N O2
• Molecular Weight: 230.061
• Mol file: 16799-04-5.mol

Synonyms:1-(2-Bromoethyl)-3-nitrobenzene;m-Nitrophenethyl bromide; b-(m-Nitrophenyl)ethylbromide

Chemical Property of 1-(2-Bromoethyl)-3-nitrobenzene

Chemical Property:

• Melting Point: 30-34 °C
• Boiling Point: 136-138 °C/0.5 mmHg
• Density: 1.562±0.06 g/cm3(Predicted)

Purity/Quality:

98%, ^*data from raw suppliers

3-Nitrophenethyl bromide 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Bromoethyl)-3-nitrobenzene

There total 4 articles about 1-(2-Bromoethyl)-3-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon tetrabromide (558-13-4) + 2-(3-nitrophenyl)ethanol (52022-77-2) → 3-(2-Bromoethyl)nitrobenzene (16799-04-5)

Guidance literature:

With triphenylphosphine; In dichloromethane;

Reference yield:

2-(3-nitrophenyl)ethanol (52022-77-2) → 3-(2-Bromoethyl)nitrobenzene (16799-04-5)

Guidance literature:

With phosphorus tribromide; In diethyl ether; Heating;

DOI:10.1002/hlca.19730560728

Reference yield:

3-nitro-benzeneacetic acid (1877-73-2) → 3-(2-Bromoethyl)nitrobenzene (16799-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄, BF₃-Et₂O / bis-(2-methoxy-ethyl) ether

2: PBr₃ / diethyl ether / Heating

With sodium tetrahydroborate; boron trifluoride diethyl etherate; phosphorus tribromide; In diethyl ether; diethylene glycol dimethyl ether;

DOI:10.1002/hlca.19730560728

upstream raw materials:

2-(3-nitrophenyl)ethanol

3-nitro-benzeneacetic acid

carbon tetrabromide

Downstream raw materials:

N-Methyl-β-(m-aminophenyl)-β'-phenyl-diethylamin

1-(2-azidoethyl)-3-nitrobenzene

3-[2-(4-phenylpiperazin-1-yl)ethyl]phenylamine

1-[2-(3-nitrophenyl)ethyl]-4-phenylpiperazine

Refernces

• 1、 -. "Aniline derivatives possessing an inhibitory effect of nitric oxide synthase". . . Retrieved 2008/06/13.