1-Bromo-3,5-dichlorobenzene

Base Information

• Chemical Name: 1-Bromo-3,5-dichlorobenzene
• CAS No.: 19752-55-7
• Molecular Formula: C6H3BrCl2
• Molecular Weight: 225.9
• Hs Code.: 29039990
• European Community (EC) Number: 243-270-7
• DSSTox Substance ID: DTXSID1066524
• Nikkaji Number: J31.735G
• Wikidata: Q72454095
• Mol file: 19752-55-7.mol

Synonyms:1-BROMO-3,5-DICHLOROBENZENE;19752-55-7;3,5-Dichlorobromobenzene;Benzene, 1-bromo-3,5-dichloro-;1-bromo-3,5-dichloro-benzene;MFCD00000584;EINECS 243-270-7;benzene, 1-bromo-3,5-dichloro;Maybridge1_000881;3,5-Dichloro bromobenzene;3,5-dichloro-1-bromobenzene;l-Brom-3,5-dichlorbenzol;3,5-dichloro bromo benzene;SCHEMBL114694;(3,5-Dichlorophenyl) bromide;DTXSID1066524;HMS544A01;STR07058;BTB 03107;CCG-50789;1-Bromo-3,5-dichlorobenzene, 98%;AKOS009156912;AC-7762;CS-W013037;SY006090;AM20060125;B2223;FT-0607474;EN300-42477;SR-01000640136-1;W-107679;BENZYL4,6-O-BENZYLIDENE-ALPHA-D-GALACTOPYRANOSIDE;F0001-0702;Z425865630

Chemical Property of 1-Bromo-3,5-dichlorobenzene

Chemical Property:

• Appearance/Colour: white to beige-brown crystalline powder
• Vapor Pressure: 0.0998mmHg at 25°C
• Melting Point: 73-75 °C(lit.)
• Refractive Index: 1.59
• Boiling Point: 230.4 °C at 760 mmHg
• Flash Point: 103.9 °C
• PSA: 0.00000
• Density: 1.744 g/cm³
• LogP: 3.75590
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 223.87952
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-3,5-dichlorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C=C1Cl)Br)Cl
• Uses: 1-Bromo-3,5-dichlorobenzene, is a building block used in the synthesis of halogenated chemical compounds, such as polychlorinated biphenyls (PCBs).

Technology Process of 1-Bromo-3,5-dichlorobenzene

There total 12 articles about 1-Bromo-3,5-dichlorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,5-dichlorobenzenediazonium tetrafluoroborate → 1-bromo-3,5-dichlorobenzene (19752-55-7)

Guidance literature:

With dibenzo-18-crown-6; potassium bromide; copper(ll) bromide; 1,10-Phenanthroline; copper(I) bromide; In acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1055/s-2007-983784

Reference yield: 97.0%

(3,5-dichlorophenyl)hydrazine hydrochloride (63352-99-8) → 1-bromo-3,5-dichlorobenzene (19752-55-7)

Guidance literature:

With boron tribromide; dimethyl sulfoxide; at 80 ℃; for 1h;

DOI:10.1016/j.tetlet.2020.151959

Reference yield: 87.0%

2-Bromo-4,6-dichlorobenzenediazonium tetrafluoroborate → 1-bromo-3,5-dichlorobenzene (19752-55-7)

Guidance literature:

With iron(II) sulfate; N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jo00111a032

upstream raw materials:

ethanol

2,4-dichloro-6-bromoaniline

1.4-Dibrom-2.6-dichlor-benzol

5-bromo-1,3-dichloro-2-iodobenzene

Downstream raw materials:

7-(m,m'-dichlorophenyl)-2,5,-di-t-butylcyclohepta-1,3,5-triene

C₆H₃⁽²⁾HCl₂

1-(3,5-dichlorophenyl)-2-phenylethan-1-one

1-((trimethylsilyl)methyl)-3,5-dichlorobenzene

Refernces

• 1、 Phuc Tran, Dat,Nomoto, Akihiro,Mita, Soichiro,Dong, Chun-ping,Kodama, Shintaro,Mizuno, Takumi,Ogawa, Akiya. "Metal- and base-free synthesis of aryl bromides from arylhydrazines". supporting information. . Retrieved 2020/05/08.
• 2、 Beletskaya, Irina P.,Sigeev, Alexander S.,Peregudov, Alexander S.,Petrovskii, Pavel V.. "Catalytic Sandmeyer bromination". . p. 2534 - 2538. Retrieved 2008/03/13.