Cyclopentanemethylamine

Base Information

• Chemical Name: Cyclopentanemethylamine
• CAS No.: 6053-81-2
• Molecular Formula: C6H13N
• Molecular Weight: 99.1759
• Hs Code.: 2921300090
• European Community (EC) Number: 227-965-2
• DSSTox Substance ID: DTXSID40209277
• Nikkaji Number: J227.267I
• Wikidata: Q72460340
• Mol file: 6053-81-2.mol

Synonyms:Cyclopentylmethanamine;6053-81-2;Cyclopentanemethylamine;cyclopentanemethanamine;(Aminomethyl)cyclopentane;C-CYCLOPENTYL-METHYLAMINE;(CYCLOPENTYLMETHYL)AMINE;MFCD04114081;cyclopentylmethylamine;EINECS 227-965-2;CYLOPENTANEMETHANAMINE;cyclopentylmethyamine;cyclopentylmethyl amine;1-cyclopentylmethanamine;1-(cyclopentyl)methylamine;F2167-0028;DTXSID40209277;1-cyclopentylmethanamine, AldrichCPR;AKOS000138940;AB17884;CCG-358842;GS-4255;AM804123;SY025882;CS-0049622;FT-0624255;EN300-41084;P10292;J-520178

Chemical Property of Cyclopentanemethylamine

Chemical Property:

• Boiling Point: 118.8 °C at 760 mmHg
• PKA: 10.50±0.29(Predicted)
• Flash Point: 19.5 °C
• PSA: 26.02000
• Density: 0.874 g/cm³
• LogP: 1.83560
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 99.104799419
• Heavy Atom Count: 7
• Complexity: 46.1

Purity/Quality:

99% ^*data from raw suppliers

CyclopentanemethanamineHCl 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)CN

Technology Process of Cyclopentanemethylamine

There total 7 articles about Cyclopentanemethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

cyclopentylamide (3217-94-5) → cyclopentylmethylamine (6053-81-2)

Guidance literature:

cyclopentylamide; With bis(cyclopentadienyl)dihydrozirconium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; at 20 ℃; Glovebox; Inert atmosphere;

With hydrogenchloride; In diethyl ether; water; for 2h; Glovebox; Inert atmosphere;

DOI:10.1016/S1872-2067(21)63853-6

Reference yield: 90.5%

t-butyloxycarbonyl anhydride + sodium cyanoborohydride (NaBH3CN) + cyclopentanone (120-92-3) → cyclopentylmethylamine (6053-81-2)

Guidance literature:

With hydrogenchloride; sodium hydroxide; methylamine hydrochloride; In 1,4-dioxane; methanol; HCl-dioxane; water;

Reference yield: 84.0%

cyclopentanecarbonitrile (4254-02-8) → cyclopentylmethylamine (6053-81-2)

Guidance literature:

With sodium sulfate;

upstream raw materials:

2-cyclopentylacetic acid

cyclopentylamide

cyclopentanecarbonitrile

cyclopentanone

Downstream raw materials:

methyl 4-<<5-indol-3-yl>methyl>-3-methoxybenzoate

cyclohexanol

1-amino-cyclopentanemethanol

1-methylcyclopentanol

Refernces

• 1、 Formenti, Dario,Mocci, Rita,Atia, Hanan,Dastgir, Sarim,Anwar, Muhammad,Bachmann, Stephan,Scalone, Michelangelo,Junge, Kathrin,Beller, Matthias. "A State-of-the-Art Heterogeneous Catalyst for Efficient and General Nitrile Hydrogenation". supporting information. p. 15589 - 15595. Retrieved 2020/10/02.
• 2、 -. "Tricyclic Compounds As mPGES-1 Inhibitors". . . Retrieved 2012/05/07.