sodium 4-bromobenzenesulfinate

Base Information

• Chemical Name: sodium 4-bromobenzenesulfinate
• CAS No.: 34176-08-4
• Molecular Formula: C₆H₄BrO₂S*Na
• Molecular Weight: 243.056
• Mol file: 34176-08-4.mol

Synonyms:sodium 4-bromobenzenesulfinate

Chemical Property of sodium 4-bromobenzenesulfinate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Sodium4-bromobenzenesulfinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sodium 4-Bromobenzene-1-sulfinate is used in preparation of beta-ketosulfone derivatives via radical addition/oxidation reaction of aryl olefins with sodium sulfinates.

Technology Process of sodium 4-bromobenzenesulfinate

There total 9 articles about sodium 4-bromobenzenesulfinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

bromobenzene (108-86-1,52753-63-6) → sodium 4-bromobenzenesulfinate (34176-08-4)

Guidance literature:

bromobenzene; With aluminum (III) chloride; 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; In 1,2-dichloro-ethane; at 25 ℃; for 4h;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane; at 25 ℃;

DOI:10.1016/j.tetlet.2018.01.081

Reference yield: 82.0%

methyl 3-((4-bromophenyl)sulfonyl)propanoate (14223-24-6) → sodium 4-bromobenzenesulfinate (34176-08-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

DOI:10.1039/d0cc01576h

Reference yield: 70.0%

4-bromobenzenesulfonyl chloride (98-58-8) → sodium 4-bromobenzenesulfinate (34176-08-4)

Guidance literature:

With sodium hydrogencarbonate; sodium sulfite; In water; at 80 ℃; for 8h;

DOI:10.1002/adsc.201601211

upstream raw materials:

4-bromobenzenesulfonyl chloride

4-Bromophenylboronic acid

4-bromobenzenesulfonyl chloride

bromobenzene

Downstream raw materials:

(4-bromo-phenyl)-(2,4-dinitro-phenyl)-sulfone

p-Brom-benzol-β-chlor-β-cyan-ethyl-sulfon

4-Brom-benzolsulfonylcyanid

C₇H₄BrNO₂S₂

Refernces

• 1、 Chen, Guang-Le,He, Shi-Hui,Cheng, Liang,Liu, Feng. "Copper-Catalyzed N-Directed Distal C(sp3)-H Sulfonylation and Thiolation with Sulfinate Salts". supporting information. p. 8338 - 8342. Retrieved 2021/10/25.
• 2、 Li, Yuxiu,Li, Xiangqian,Li, Xiaowei,Shi, Dayong. "Visible-light-promotedE-selective synthesis of α-fluoro-β-arylalkenyl sulfidesviathe deoxygenation/isomerization process". supporting information. p. 2152 - 2155. Retrieved 2021/03/06.