Technology Process of 3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene
There total 3 articles about 3-ethoxy-16-methylene-17α-dimethylphenylsilylethynyl-17β-hydroxy-19-norandrosta-3,5-diene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(dimethylphenylsilyl)acetylene;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
Inert atmosphere;
3-ethoxy-16-methylene-19-norandrosta-3,5-dien-17-one;
In
tetrahydrofuran;
for 0.005h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / Acidic conditions
2.1: oxalic acid diethyl ester / 0.1 h
2.2: 0.2 h / 0 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 0.01 h / Inert atmosphere
With
oxalic acid diethyl ester; lithium hexamethyldisilazane;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalic acid diethyl ester / 0.1 h
1.2: 0.2 h / 0 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 0.01 h / Inert atmosphere
With
oxalic acid diethyl ester; lithium hexamethyldisilazane;
In
tetrahydrofuran;