734-32-7Relevant articles and documents
Jacquesy et al.
, p. 4739 (1972)
Method for preparing 19-desmethyl-4-androstene-3,17-diketone by using one-pot method
-
Paragraph 0019, (2018/04/03)
The invention discloses a method for preparing 19-desmethyl-4-androstene-3,17-diketone by using a one-pot method. The method for preparing 19-desmethyl-4-androstene-3,17-diketone comprises the step oftaking a compound 1 as a starting raw material, carrying out hydrogenation and condensation reaction by using the one-pot method, thus obtaining a 19-desmethyl-4-androstene-3,17-diketone coarse product 3, wherein reaction formulas are as follows: as shown in the specification. According to the method, the high-purity 19-desmethyl-4-androstene-3,17-diketone coarse product can be obtained under a total mole yield of 92 percent or above, so that the method is low in cost, environmentally friendly and suitable for industrial production.
Preparation method of 19-demethylation-4-androstenedione
-
, (2017/08/30)
The invention discloses a preparation method of 19-demethylation-4-androstenedione and belongs to the technical field of medical intermediate processing. The preparation method comprises the following steps: (1) carrying out esterification reaction; (2) carrying out ketalation; (3) carrying out reduction reaction; (4) carrying out hydrolysis reaction; (5) carrying out esterification reaction; (6) carrying out addition reaction; (7) carrying out cyclization and hydrolysis reaction; (8) carrying out oxidation, dechloridation and ring-opening reaction; and (9) carrying out oxidation and decarboxylation reaction. The preparation method disclosed by the invention has the advantages that environmental pollution is small, usage amounts of a solvent and water are smaller, temperature sensitivity is low, control is easy, and yield is high; a chlorinating agent is adopted, so that reaction yield is increased; 1,3-dichloro-5,5-dimethylhydantoin is adopted, so that the reaction yield is further increased; and sodium hydrogen carbonate is adopted, so that final decarboxylic reaction yield is increased, and external standards and appearance of a product can be improved.