4-amino-N-(4-carbamoylphenyl)benzamide

Base Information

• Chemical Name: 4-amino-N-(4-carbamoylphenyl)benzamide
• CAS No.: 74441-06-8
• Molecular Formula: C₁₄H₁₃N₃O₂
• Molecular Weight: 255.276
• Hs Code.: 2924299090
• European Community (EC) Number: 277-874-7
• DSSTox Substance ID: DTXSID20995964
• Nikkaji Number: J349.469A
• Wikidata: Q72438122
• Mol file: 74441-06-8.mol

Synonyms:4-amino-N-(4-carbamoylphenyl)benzamide;74441-06-8;Benzamide, 4-amino-N-[4-(aminocarbonyl)phenyl]-;4-AMINO-N-[4-(AMINOCARBONYL)PHENYL]BENZAMIDE;4-Amino-N-(4-(aminocarbonyl)phenyl)benzamide;EINECS 277-874-7;SCHEMBL3282206;4-(4-aminobenzoylamino)benzamide;DTXSID20995964;MFCD00272411;AKOS000158320;AS-63539;CS-0149917;FT-0702818;4-Amino-N-[(4 Aminocarbonyl)-phenyl]benzamide;D82386;EC 277-874-7;A838133;W-111505;4-Amino-N-(4-carbamoylphenyl)benzene-1-carboximidic acid

Chemical Property of 4-amino-N-(4-carbamoylphenyl)benzamide

Chemical Property:

• Appearance/Colour: White Powder
• Vapor Pressure: 1.1E-07mmHg at 25°C
• Refractive Index: 1.71
• Boiling Point: 432.5 °C at 760 mmHg
• PKA: 13.86±0.70(Predicted)
• Flash Point: 215.4 °C
• PSA: 98.21000
• Density: 1.348 g/cm³
• LogP: 2.97450
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 255.100776666
• Heavy Atom Count: 19
• Complexity: 330

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-N-(4-carbamoylphenyl)benzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N)N
• Use Description: p-Aminobenzoyl benzamide, also known as PABA (para-aminobenzoic acid) benzamide, has diverse applications in different fields. In the cosmetics and skincare industry, PABA benzamide is utilized as a UV absorber and sunscreen agent due to its ability to absorb and block ultraviolet (UV) radiation, protecting the skin from the harmful effects of sun exposure. In the pharmaceutical field, it has been historically used as a component in certain medications, particularly in dermatological treatments and topical ointments for conditions like psoriasis. Moreover, PABA benzamide has applications in organic chemistry as a chemical intermediate, allowing for the synthesis of various organic compounds. Its multifunctional properties make it a valuable component in both skincare products and chemical synthesis, contributing to sun protection, medical treatments, and scientific research.

Technology Process of 4-amino-N-(4-carbamoylphenyl)benzamide

There total 2 articles about 4-amino-N-(4-carbamoylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%

N-(4-carbamoylphenyl)-4-nitrobenzamide (93839-21-5) → 4-amino-N-(4-carbamoylphenyl)benzamide (74441-06-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In N,N-dimethyl acetamide; at 50 - 65 ℃; for 1h; under 11251.1 Torr; Temperature; Time; Concentration; Autoclave;

DOI:10.1007/s11164-012-0753-0

Reference yield: 30.0%

4-nitro-benzoic acid (62-23-7) → 4-amino-N-(4-carbamoylphenyl)benzamide (74441-06-8)

Guidance literature:

Multistep reaction;

DOI:10.1081/SCC-120003608

upstream raw materials:

4-nitro-benzoic acid

N-(4-carbamoylphenyl)-4-nitrobenzamide

Refernces

• 1、 Roedel, Martin,Thieme, Florian,Buchholz, Herwig,Koenig, Burkhard. "Heterogeneous catalyzed reduction of polymer-bound nitroarenes". . p. 1181 - 1187. Retrieved 2007/10/03.