2-(Trimethylazaniumyl)acetate hydrochloride

Base Information

• Chemical Name: 2-(Trimethylazaniumyl)acetate hydrochloride
• CAS No.: 590-46-5
• Molecular Formula: C5H12ClNO2
• Molecular Weight: 153.609
• Hs Code.: 29239000
• Mol file: 590-46-5.mol

Synonyms:Acidol;Cystadane;Betainehydrochloride;C5-H12-N-O2.Cl;NCGC00094983-01;2-(Trimethylammonio)acetate hydrochloride;2-(trimethylazaniumyl)acetate hydrochloride;SPECTRUM1503007;HMS1921P20;CCG-40089;AKOS024462480;DS-7421;NCGC00094983-02;B0458;FT-0663079

Chemical Property of 2-(Trimethylazaniumyl)acetate hydrochloride

Chemical Property:

• Appearance/Colour: colorless to white crystals
• Vapor Pressure: 0Pa at 25℃
• Melting Point: 241-242 °C(lit.)
• PSA: 37.30000
• Density: 1 g/cm3
• LogP: -3.21880
• Storage Temp.: Store below +30°C.
• Solubility.: H2O: 1 M at 20 °C, clear, colorless
• Water Solubility.: 64.7 g/100 mL (25 ºC)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 153.0556563
• Heavy Atom Count: 9
• Complexity: 87.6

Purity/Quality:

99.2% ^*data from raw suppliers

Betaine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xi,Xn
• Statements: 36-36/37/38-20/21/22
• Safety Statements: 26-39-24/25-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+](C)(C)CC(=O)[O-].Cl
• Recent EU Clinical Trials: BetH?m2012: A monocenter, single-blind, randomized, 2-armed, placebo-controlled, cross-over study to investigate coagulation markers in patients with haemophilia A after administration of Betain
• Description: Betaine hydrochloride is a vitamin-like substance that is a source of hydrochloric acid and aids the production of stomach acid. Gastric acid also helps protect the gastrointestinal tract from harmful bacteria. A normal level of gastric acid in the stomach—100,000-1,000,000 times more acidic than water—is sufficient to destroy bacteria, but some people produce deficient amounts of stomach acid, a condition that may lead to bacterial and parasitic infections of the intestines. One study showed that fasting people with normal gastric acid levels in the stomach had almost no bacteria in the small in- testine, while individuals with low levels of hydrochloric acid had some bacterial colonization in the stomach.Betaine hydrochloride is therefore recommended by some medical practitioners to sustain a healthy and normal production of stomach acid, especially to those that suffer from disorders such as allergies and asthma. Betaine hydrochloride is a synthesized chemical, and is not obtained from any plant or animal source. Gastric acid is produced by stomach cells, and is not available from any food source. Occasionally, betaine (C5H11NO2 )is recommended to reduce blood levels of homocysteine, which is associated with heart disease. This form of betaine is different from betaine hydrochlo- ride, and is available only with a doctor’s prescription.
• Uses: Betaine hydrochloride can be used as antiarteriosclerotic, hypolipaemic, hepatoprotectant. antiprotozoal, coccidiostat Betaine is used as gastric acidifier.naturopaths have long held that low stomach acid is a widespread problem that interferes with the digestion and absorption of nutrients. Betaine hydrochloride is one of the most common recommendations for this condi- tion. It helps make some minerals and other nutrients more absorbable, and may be especially helpful with nu- tritional supplements, which are often taken in tablets or capsules that may not be easily digested.
• Indications: Betaine hydrochloride may be used as a lipotropic. Lipotropics aid in preventing the accumulation of fat in the liver, and usually help in the detoxification of metabolic wastes and toxins. They may be used to help with weight loss. Betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria, a condition in which an abnormally low amount of hydrochloric acid is in the stomach. It has been used in preparations for the treatment of liver disorders, hypokalaemia (abnormally low levels of potassium in the blood), CO2 production in double contrast radiography, and high homocysteine. Betaine hydrochloride has also been used to treat tic douloreux (a condition which involves spasmodic pain along the course of a facial nerve), cystinuria (a hereditary defect that results in recurrent kidney stone formation), and vitiligo (a condition that is characterized by milky-white patches on otherwise normal skin).
• Biological Functions: Betaine hydrochloride and pepsin are naturally occurring gastric-juice components that render nutrients available for absorption and biological acitivity. Specifically, Betaine hydrochloride is an acidic form of betaine, which promotes optimal gastric lumen acidity and pepsin is a protein-digesting enzyme that catalyzes the splitting of peptide bonds. Betaine HCl is an excellent source of hydrochloric acid, also known as stomach acid. Supplementing with betaine HCl can be very beneficial, as insufficient production of hydrochloric acid is fairly widespread and often overlooked. Certain situations, such as normal aging, can decrease the body’s natural production of HCl.
• Clinical Use: Betaine hydrochloride (pronounced beta-een) is the acid form of trimethyiglycine (TMG). It is available as an over-the-counter drug. The most common use of betaine hydrochloride is as digestive aid for people who suffer from low gastric acidity (hypochlorhydria), a common complaint in the elderly and a cause of chronic indigestion. Although such a practice is unwise. betaine hydrochloride can be of use in cases of overeating. Gourmands, in particular, suffer less discomfort after indulgences if they take betaine hydrochloride with their feasts. Betaine hydrochloride is not only a digestive aid, but it also confers all the benefits of TMG (see next). However, betaine hydrochloride should not be used by anyone with chronic indigestion or heartburn without first seeking medical evaluation of the problem to make sure that there is not a more serious underlying condition. such as stomach ulcers. Betaine hydrochloride should be taken only with meals, and then only after first eating a few bites of food. The usual dose of betaine hydrochloride for hypochlorhydria is 500 milligrams. which is equivalent to 1.1 cubic centimeter (about a quarter teaspoon) of pharmaceutical Dilute Hydrochloric acid.
• Drug interactions: People taking nonsteroidal anti-inflammatory drugs (NSAIDs), cortisone-like drugs, or other medications that could cause peptic ulcers should not take betaine hy- drochloride.

Technology Process of 2-(Trimethylazaniumyl)acetate hydrochloride

There total 16 articles about 2-(Trimethylazaniumyl)acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

Trimethylammoniumessigsaeurebetain-methylester-chlorid (3032-10-8) → betaine hydrochloride (590-46-5)

Guidance literature:

With water; at 100 ℃; for 5h; Temperature; Reagent/catalyst; Molecular sieve;

Reference yield: 98.4%

N-<(ethoxycarbonyl)methyl>trimethylammonium chloride (3032-11-9) → betaine hydrochloride (590-46-5)

Guidance literature:

With water; at 60 ℃; for 5h; Molecular sieve;

Reference yield: 98.2%

betaine butyl ester chloride (3032-13-1) → betaine hydrochloride (590-46-5)

Guidance literature:

With water; at 80 ℃; for 4h; Temperature; Molecular sieve;

upstream raw materials:

bis-(trimethylammonio-acetyl)-amine; dichloride

betaine

methoxycarbonylmethylamine

(2,2,3,3,3-Pentafluoropropyl)trimethylammonium iodide

Downstream raw materials:

Cyclohexylsulfanylcarbonylmethyl-trimethyl-ammonium; chloride

carbon dioxide

tetramethlyammonium chloride

N-chlorobetainyl chloride

Refernces

• 1、 -. "Compound containing quaternary ammonium salt ions and peroxycarboxylic acid groups in structure as well as preparation method and application of compound". Paragraph 0118; 0119; 0120. . Retrieved 2018/11/22.
• 2、 Chiappe, Cinzia,Rajamani, Sunita,D'Andrea, Felicia. "A dramatic effect of the ionic liquid structure in esterification reactions in protic ionic media". . p. 137 - 143. Retrieved 2013/02/25.