4-chlorophenylmagnesium iodide

Base Information

• Chemical Name: 4-chlorophenylmagnesium iodide
• CAS No.: 7270-47-5
• Molecular Formula: C₆H₄ClIMg
• Molecular Weight: 262.76
• Mol file: 7270-47-5.mol

Synonyms:4-chlorophenylmagnesium iodide

Chemical Property of 4-chlorophenylmagnesium iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chlorophenylmagnesium iodide

There total 1 articles about 4-chlorophenylmagnesium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Chloro-4-iodobenzene (637-87-6) → 4-chlorophenylmagnesium iodide (7270-47-5)

Guidance literature:

With iodine; magnesium; In diethyl ether; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00434

Reference yield: 92.0%

2-Phenylbenzaldehyde (1203-68-5) + 4-chlorophenylmagnesium iodide (7270-47-5) → α-(4'-chlorophenyl)biphenyl-2-methanol (113769-85-0)

Guidance literature:

In diethyl ether; at 0 - 20 ℃; for 14h;

Reference yield: 77.0%

C12H14O2S + 4-chlorophenylmagnesium iodide (7270-47-5) → (Z)-(Ss,R)-3-(4-chlorophenyl)-2-methyl-1-(4-tolylsulfinyl)but-1-en-3-ol

Guidance literature:

With magnesium mono perphthalate; In methanol; at 20 ℃; diastereoselective reaction; Cooling;

DOI:10.1016/j.tetlet.2013.12.108

upstream raw materials:

1-Chloro-4-iodobenzene

Downstream raw materials:

p-chlorotriphenylmethanol

2-chloro-1,1-bis-(4-chloro-phenyl)-2-fluoro-ethanol

2-bromo-4',4''-dichloro-trityl chloride

2-benzyl-4'-chloro-benzophenone

Refernces

• 1、 Muramatsu, Wataru,Nakano, Kimihiro. "Efficient C(sp3)-H bond functionalization of isochroman by azadol catalysis". supporting information. p. 1549 - 1552. Retrieved 2015/03/30.