1H-Indol-2-amine hydrochloride

Base Information

• Chemical Name: 1H-Indol-2-amine hydrochloride
• CAS No.: 36946-70-0
• Molecular Formula: C8H8 N2
• Molecular Weight: 132.165
• ChEMBL ID: CHEMBL2392114
• DSSTox Substance ID: DTXSID80958131
• Mol file: 36946-70-0.mol

Synonyms:1H-Indol-2-amine hydrochloride;2-AMINOINDOLE HYDROCHLORIDE;27878-37-1;36946-70-0;2-aminoindole HCl;1H-indol-2-amine;hydrochloride;1H-INDOL-2-AMINE HCL;3H-indol-2-amine hydrochloride;CHEMBL2392114;1H-Indol-2-amine, monohydrochloride;SCHEMBL5435898;DTXSID80958131;1H-Indol-2-ylamine;AMY17774;BCP27951;MFCD06798215;AKOS015898503;AB92501;SB18479;AC-24549;AS-41181;A6354;CS-0311853;FT-0611251;1H-Indol-2-amine--hydrogen chloride (1/1);A876850

Chemical Property of 1H-Indol-2-amine hydrochloride

Chemical Property:

• Vapor Pressure: 6.6E-06mmHg at 25°C
• Melting Point: 215-220 ºC dec.
• Boiling Point: 372.4°C at 760 mmHg
• PKA: 18.89±0.30(Predicted)
• Flash Point: 179°C
• PSA: 41.81000
• Density: 1.268±0.06 g/cm3(Predicted)
• LogP: 3.13330
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 168.0454260
• Heavy Atom Count: 11
• Complexity: 124

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-AminoindoleHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C(N2)N.Cl

Technology Process of 1H-Indol-2-amine hydrochloride

There total 14 articles about 1H-Indol-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(1H-indol-1-yl)(pyridin-2-yl)methanone (1131148-08-7) → indoleamine (36946-70-0)

Guidance literature:

(1H-indol-1-yl)(pyridin-2-yl)methanone; With tert.-butylnitrite; copper diacetate; In 1,4-dioxane; at 70 ℃; for 16h;

With hydrazine hydrate; FeCl₃/C; In 1,4-dioxane; ethanol; at 70 ℃;

Reference yield: 88.0%

2-nitroindole (193686-70-3) → indoleamine (36946-70-0)

Guidance literature:

With sodium tetrahydroborate; In water; at 60 ℃; for 0.25h; Sonication;

DOI:10.1002/aoc.5223

Reference yield: 52.0%

2-nitro-benzeneacetonitrile (610-66-2) → indoleamine (36946-70-0)

Guidance literature:

With hydrogenchloride; In ethanol; at 30 ℃; for 3h;

DOI:10.1271/bbb1961.45.2031

upstream raw materials:

2-nitro-benzeneacetonitrile

2-aminophenylacetonitrile

sodium ethanolate

(2-formylamino-phenyl)-acetonitrile

Downstream raw materials:

2,4-diphenyl-9H-pyrimido[4,5-b]indole

4-(chlorodifluoromethyl)-2-phenyl-9H-pyrido[2,3-b]indole

1,2,3,4-tetrafluoro-6H-indolo[2,3-b]quinoline

2-phenyl-4-(trifluoromethyl)-9H-pyrido[2,3-b]indole

Refernces

• 1、 -. "Method for preparing 2-aminoindole derivative". Paragraph 0016; 0017. . Retrieved 2018/09/12.
• 2、 Matsumoto,Yoshida,Tomita. "Synthesis and mutagenic activity of alkyl derivatives of 2-amino-9H-pyrido[2,3-b]indole". . p. 2031 - 2035. Retrieved 2007/10/02.