4-Chloro-N-methylpicolinamide

Base Information

• Chemical Name: 4-Chloro-N-methylpicolinamide
• CAS No.: 220000-87-3
• Molecular Formula: C7H7ClN2O
• Molecular Weight: 170.598
• Hs Code.: 2942000000
• DSSTox Substance ID: DTXSID80363105
• Nikkaji Number: J1.145.124A
• Wikidata: Q72489418
• ChEMBL ID: CHEMBL4163507
• Mol file: 220000-87-3.mol

Synonyms:220000-87-3;4-Chloro-N-methylpicolinamide;4-Chloro-N-methylpyridine-2-carboxamide;N-Methyl-4-chloropyridine-2-carboxamide;4-Chloro-N-methyl-2-pyridinecarboxamide;N-METHYL 4-CHLOROPICOLINAMIDE;2-Pyridinecarboxamide, 4-chloro-N-methyl-;CHEMBL4163507;MFCD02185921;4-CHLOROPYRIDINE-2-CARBOXYLIC ACID METHYLAMIDE;4-Chloranyl-~{n}-Methyl-Pyridine-2-Carboxamide;4-Chloro-N-methylpyridine-2-carboxamide (>90per cent);7MU;4-chloro-n-methyl-2-pyridine carboxamide;4-chloro-N-methyl-pyridine-2-carboxamide;(4-chloro(2-pyridyl))-N-methylcarboxamide;(4-chloro-(2-pyridyl))-N-methylcarboxamide;N-methyl4-chloropicolinamide;N-methyl-4-chloropicolinamide;SCHEMBL177518;4-chloro-N-methylpicolinarnide;4-chloro-N-methyl picolinamide;DTXSID80363105;HMS1746A21;BCP04087;CS-M2758;BDBM50277367;CL0248;4chloro-n-methyl-2-pyridinecarboxamide;AKOS001123699;4-chloro-N-methyl-2-pyndinecarboxamide;4M-538S;AB11548;AC-6125;CS-O-31808;PB41968;2-(N-methylcarbamoyl)-4-chloropyridine;4-chloro(2-pyridyl)-n-methylcarboxamide;4-chloro(2-pyridyl)-N-methyl-carboxamide;4-chloro-N- methyl-2-pyridinecarboxamide;4-chloro-N-methyl -2-pyridinecarboxamide;SY007502;A4725;AM20070293;C2793;FT-0646018;EN300-13787;(4-Chloro-(2-Pyridyl)-N-Methyl Carboxamide);4-chloro-pyridine-2-carboxylic acid methylamide;4-chloro-pyridine-2-carboxylic acid methyl amide;4-Chloro-N-methylpyridine-2-carboxamide (>90%);4-chloro-N-Methylpyridine-2-carboxamide, AldrichCPR;J-014411;J-515175;Z94601331;N-Methyl-4-chloro-2-pyridinecarboxamide

Chemical Property of 4-Chloro-N-methylpicolinamide

Chemical Property:

• Appearance/Colour: pale-yellow solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 41-43 °C
• Refractive Index: 1.575
• Boiling Point: 317.8 °C at 760 mmHg
• PKA: 13.41±0.46(Predicted)
• Flash Point: 146 °C
• PSA: 41.99000
• Density: 1.264 g/cm³
• LogP: 1.48550
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly), Met
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.0246905
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-N-methylpyridine-2-carboxamide(>90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)C1=NC=CC(=C1)Cl
• Uses: 4-Chloro-N-methylpyridine-2-carboxamide (>90%) (cas# 220000-87-3) is a compound useful in organic synthesis.

Technology Process of 4-Chloro-N-methylpicolinamide

There total 42 articles about 4-Chloro-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

4-Chloro-pyridine-2-carboxylic acid methyl ester (24484-93-3) + methylamine (74-89-5) → 4-chloro-N-methylpicolinamide (220000-87-3)

Guidance literature:

With magnesium chloride; In tetrahydrofuran; at 20 ℃; for 2.25h;

Reference yield: 98.0%

methylamine (74-89-5) + methyl 4-chloropyridine-2-carboxylate hydrochloride (176977-85-8) → 4-chloro-N-methylpicolinamide (220000-87-3)

Guidance literature:

In tetrahydrofuran; at 0 - 10 ℃; for 6h; Temperature; Solvent;

Reference yield: 97.0%

methyl 4-chloropyridine-2-carboxylate hydrochloride (176977-85-8) → 4-chloro-N-methylpicolinamide (220000-87-3)

Guidance literature:

With methylamine; In tetrahydrofuran; methanol; ethyl acetate;

upstream raw materials:

4-chloro-pyridine-2-carbonyl chloride

4-Chloro-pyridine-2-carboxylic acid methyl ester

methylamine

4-Chloropyridine

Downstream raw materials:

4-(2-(N-methylcarbamoyl)-4-pyridyloxy)-2-chlorophenyl-(2,2,2-trifluoro)acetamide

4-(2-(N-methylcarbamoyl)-4-pyridyloxy)-2-methylaniline hydrochloride

3-(4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)propanoic acid

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

Refernces

• 1、 El-Damasy, Ashraf Kareem,Lee, Ju-Hyeon,Seo, Seon Hee,Cho, Nam-Chul,Pae, Ae Nim,Keum, Gyochang. "Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase inhibitory activities". . p. 201 - 216. Retrieved 2016.
• 2、 Wang, Min,Xu, Shan,Wu, Chunjiang,Liu, Xiaobo,Tao, Hong,Huang, Yanli,Liu, Yongchan,Zheng, Pengwu,Zhu, Wufu. "Design, synthesis and activity of novel sorafenib analogues bearing chalcone unit". . p. 5450 - 5454. Retrieved 2016.
• 3、 -. "METHODS OF USING REBASTINIB IN THE TREATMENT OF DISORDERS". Paragraph 0468. . Retrieved 2021/09/10.
• 4、 Wilde, Myron,Arzur, Danielle,Baratte, Blandine,Lefebvre, Dorian,Robert, Thomas,Roisnel, Thierry,Le Jossic-Corcos, Catherine,Bach, Stéphane,Corcos, Laurent,Erb, William. "Regorafenib analogues and their ferrocenic counterparts: Synthesis and biological evaluation". supporting information. p. 19723 - 19733. Retrieved 2020/12/04.