N-Boc-ethylenediamine

Base Information

• Chemical Name: N-Boc-ethylenediamine
• CAS No.: 57260-73-8
• Molecular Formula: C7H16N2O2
• Molecular Weight: 160.216
• Hs Code.: 29241990
• European Community (EC) Number: 611-490-6
• DSSTox Substance ID: DTXSID70276679
• Nikkaji Number: J582.375G
• Wikidata: Q72449218
• Mol file: 57260-73-8.mol

Synonyms:N-Boc-ethylenediamine;57260-73-8;tert-Butyl N-(2-aminoethyl)carbamate;tert-butyl (2-aminoethyl)carbamate;tert-butyl 2-aminoethylcarbamate;n-t-boc-ethylenediamine;N-tert-Boc-ethylenediamine;1-boc-ethylenediamine;NH2-C2-NH-Boc;(2-amino-ethyl)-carbamic acid tert-butyl ester;MFCD00191871;N-(2-Aminoethyl)carbamic Acid tert-Butyl Ester;N-Boc-1,2-diaminoethane;n-boc-ethane-1,2-diamine;tert-butyl(2-aminoethyl)carbamate;tert-butyl-(2-aminoethyl)carbamate;N-(tert-butyloxycarbonyl)ethylenediamine;mono-n-tert-butyloxycarbonylethylenediamine;N-(tert-Butoxycarbonyl)-1,2-diaminoethane;CARBAMIC ACID, (2-AMINOETHYL)-, 1,1-DIMETHYLETHYL ESTER;BUTTPARK 27\08-29;mono-(BOC)-ethylene diamine;n-boc-ethylendiamine;N-Boc ethylenediamine;N-(Boc)ethylenediamine;N-Boc-Ethylene diamine;N-Boc-ethylene-diamine;monoboc ethylene diamine;N-(2-aminoethyl)(tert-butoxy)carboxamide;BocNH-CH2CH2NH2;mono-boc-ethylene diamine;Mono-BOC-Ethylenediamine;n-(t-boc)ethylenediamine;N-(2-Aminoethyl)carbamicacidtert-butylester;BOC-ETHYLENEDIAMINE;mono-N-Boc-ethylenediamine;n-boc-(2-aminoethyl)amine;1-Boc-amino-ethan-2-amine;2-(N-BOC-Amino)ethylamine;SCHEMBL34362;t-butyl 2-aminoethylcarbamate;Mono-Boc-1,2-ethylenediamine;t-butyl(2-aminoethyl)carbamate;Mono-N-Boc-1,2-diaminoethane;2-(BOC-AMINO)ETHYLAMINE;t-butyl (2-aminoethyl)carbamate;tert-Butyl-2-aminoethylcarbamate;DTXSID70276679;tert-butyl 2-amino-ethylcarbamate;2-t-butoxycarbonylamino-ethylamine;N-t-butoxycarbonylethylene diamine;Carbamic acid, N-(2-aminoethyl)-, 1,1-dimethylethyl ester;N-t-Butyloxycarbonylethylenediamine;t-butyl n-(2-aminoethyl)carbamate;N-(t-Butoxycarbonyl)ethylenediamine;tert-butyl 2-aminoethylaminoformate;BCP27418;CS-B0430;STR05367;tert-butyl-n(2-aminoethyl)carbamate;N-tert.butoxycarbonyl-ethylenediamine;t-butyl N-(2-aminoethyl)-carbamate;2-tert-butoxycarbonylamino-ethylamine;AM1085;N-(t-butyloxycarbonyl)ethylenediamine;N-(tert-Butoxycarbonyl)ethylendiamine;STK802421;N-tert-butyloxycarbonyl-ethylendiamine;tert butyl n-(2-aminoethyl)carbamate;tert-butyl (n-2-aminoethyl)carbamate;tert-butyl-n-(2-aminoethyl)carbamate;2-(tert-butoxycarbonylamino)ethylamine;2-tert.-butoxycarbonylamino-ethylamine;AKOS000221752;n-(2-aminoethyl)(t-butoxy)carboxamide;PROTAC Linker 22PROTAC Linker 22;tert-butyl n-(2-aminoethyl) carbamate;AB04628;AC-2379;GC10190;N- (tert-butoxycarbonyl)ethylenediamine;N-(tert-butoxycarbonyl)-ethylenediamine;N-t-butyloxycarbonyl-1,2-diaminoethane;tert-butyl N-(2-aminoethyl)-carbamate;1,1-dimethylethyl 2-aminoethylcarbamate;2-(tert-butyloxycarbonylamino)ethylamine;mono tert-butyloxycarbonylethylenediamine;Mono tert.butyloxycarbonylethylenediamine;n-(2-aminoethyl) (t-butoxy)carboxamide;n-(2-aminoethyl)(t-butoxy) carboxamide;N-(tertbutyloxycarbonyl)ethylene diamine;N-tert.-butyloxycarbonyl-ethylenediamine;mono-tert-butyloxycarbonyl ethylenediamine;N-t-butoxycarbonyl-1,2-ethylene-diamine;BP-20547;BP-31035;HY-40171;mono-n-(t-butoxycarbonyl)-ethylenediamine;N-(2-t-butoxycarbonylaminoeth-1-yl)amine;N-Boc-ethylenediamine, >=98.0% (NT);SY002861;N-(t-Butyloxycarbonyl)-1,2-diaminoethane;(2-aminoethyl)carbamic acid tert-butyl ester;A1371;A8167;FT-0629323;N-(tert-butoxy carbonyl)-1,2-diaminoethane;N-(tert-Butoxycarbonyl)-1,2-ethylenediamine;N-(TERT-BUTOXYCARBONYL)ETHYLENEDIAMINE;(2-Amino-ethyl)-carbamic acid tert-butylester;(2-amino-ethyl)-carbamic acid tertbutyl ester;(2-amino-ethyl)carbamic acid tert-butyl ester;(2-aminoethyl) carbamic acid tert-butyl ester;(2-aminoethyl)-carbamic acid tert-butyl ester;EN300-51287;N-(2-Aminoethyl)carbamic Acid ter-tbutylester;(2-amino-ethyl)-carbamic acid tert butyl ester;(2-amino-ethyl)-carbamic acid-tert-butyl ester;N-(1,1-dimethylethoxycarbonyl)-ethylene diamine;N-(2-aminoethyl) carbamic acid tert-butyl ester;1,1-DIMETHYLETHYL (2-AMINOETHYL)CARBAMATE;J-524351;(2-aminoethyl)-carbamic acid, 1,1-dimethylethyl ester;F0001-1495;N-(2-Aminoethyl)carbamic Acid 1,1-Dimethylethyl Ester

Chemical Property of N-Boc-ethylenediamine

Chemical Property:

• Appearance/Colour: colorless to very light yellow oily liquid
• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: n20/D 1.458(lit.)
• Boiling Point: 252.778 °C at 760 mmHg
• PKA: 12.40±0.46(Predicted)
• Flash Point: 106.677 °C
• PSA: 64.35000
• Density: 1.001 g/cm³
• LogP: 1.56100
• Storage Temp.: Refrigerator (+4°C)
• Sensitive.: Air Sensitive
• Water Solubility.: Miscible with methanol and chloroform. Slightly miscible with water.
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 160.121177757
• Heavy Atom Count: 11
• Complexity: 129

Purity/Quality:

99% ^*data from raw suppliers

N-Boc-ethylenediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCCN
• Uses: suzuki reaction N-Boc-ethylenediamine is used in the synthesis of Thyronamine derivatives and analogs. N-Boc-ethylenediamine is used in the synthesis of thyronamine derivatives. It is also used in the preparation of (2-isothiocyanato-ethyl)-carbamic acid tert-butyl ester by reacting with carbon disulfide. Further, it is used in both oligonucleotide and peptide synthesis.

Technology Process of N-Boc-ethylenediamine

There total 6 articles about N-Boc-ethylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

di-tert-butyl dicarbonate (24424-99-5) + ethylenediamine (107-15-3,85404-18-8) → N-BOC-1,2-diaminoethane (57260-73-8) + tert-butyl N-2-[(tert-butoxycarbonyl)amino]ethylcarbamate (33105-93-0)

Guidance literature:

In chloroform; for 2h; Ambient temperature;

DOI:10.1016/0223-5234(91)90133-8

Reference yield: 90.0%

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) + ethylenediamine (107-15-3,85404-18-8) → N-BOC-1,2-diaminoethane (57260-73-8) + tert-butyl N-2-[(tert-butoxycarbonyl)amino]ethylcarbamate (33105-93-0)

Guidance literature:

With triethylamine; In chloroform; for 4h; Ambient temperature;

DOI:10.1021/jm00400a002

Reference yield:

ethyl 5-[3-[(3-chlorobenzyl)oxy]phenyl]-4-thiazolecarboxylate → t-butyl [2-[5-[3-[(3-chlorobenzyl)oxy]phenyl]-4-thiazolecarboxamido]ethyl]carbamate (127918-80-3) + N-BOC-1,2-diaminoethane (57260-73-8)

Guidance literature:

upstream raw materials:

di-tert-butyl dicarbonate

ethylenediamine

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

3-fluoro-4-(4-trifluoromethyl-benzyloxy)-benzoic acid

Downstream raw materials:

[(2-tert-Butoxycarbonylamino-ethylamino)-methyl]-phosphonic acid diphenyl ester

[2-(4-chlorobenzylamino)ethyl]carbamic acid tert-butyl ester

tert-butyl [2-(1-phenethylpiperidin-4-ylamino)ethyl]carbamate

N-(tert-butoxycarbonyl)-N'-(2-nitrobenzenesulfonyl)ethylenediamine

Refernces

• 1、 Jong, Thingsoon,Bradley, Mark. "Flow-mediated synthesis of Boc, Fmoc, and Dd iv monoprotected diamines". supporting information. p. 422 - 425. Retrieved 2015/03/03.
• 2、 Hickey, Shane M.,Ashton, Trent D.,Khosa, Simren K.,Pfeffer, Frederick M.. "An optimised synthesis of 2-[2,3-Bis(tert -butoxycarbonyl)guanidino] ethylamine". scheme or table. p. 1779 - 1782. Retrieved 2012/08/29.