Technology Process of N-[5-(2-amino-3-bromo-6-quinolinyl)-4-methyl-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide
There total 11 articles about N-[5-(2-amino-3-bromo-6-quinolinyl)-4-methyl-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium acetate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane;
at 65 ℃;
for 7h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: pyridine / dichloromethane / 2 h / 20 °C
2: sulfuric acid / 2 h / 0 - 20 °C
3: N-Bromosuccinimide / dichloromethane; N,N-dimethyl-formamide / 22 h / 20 °C
4: trichlorophosphate / 1 h / 100 °C
5: triethylamine / butan-1-ol / 29 h / 135 °C / Sealed tube
6: trifluoroacetic acid / 65 °C
7: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 7 h / 65 °C / Inert atmosphere
With
pyridine; N-Bromosuccinimide; sulfuric acid; potassium acetate; triethylamine; trifluoroacetic acid; trichlorophosphate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;
7: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide / dichloromethane; N,N-dimethyl-formamide / 22 h / 20 °C
2: trichlorophosphate / 1 h / 100 °C
3: triethylamine / butan-1-ol / 29 h / 135 °C / Sealed tube
4: trifluoroacetic acid / 65 °C
5: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 7 h / 65 °C / Inert atmosphere
With
N-Bromosuccinimide; potassium acetate; triethylamine; trifluoroacetic acid; trichlorophosphate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;
5: Suzuki Coupling;