5-Bromo-2-methoxy-4-methyl-3-nitropyridine

Base Information

• Chemical Name: 5-Bromo-2-methoxy-4-methyl-3-nitropyridine
• CAS No.: 884495-14-1
• Molecular Formula: C7H7 Br N2 O3
• Molecular Weight: 247.048
• Hs Code.: 2933399090
• Mol file: 884495-14-1.mol

Synonyms:5-Bromo-2-methoxy-4-methyl-3-nitropyridine

Chemical Property of 5-Bromo-2-methoxy-4-methyl-3-nitropyridine

Chemical Property:

• Vapor Pressure: 0.00174mmHg at 25°C
• Boiling Point: 302.8oC at 760 mmHg
• PKA: -2.34±0.28(Predicted)
• Flash Point: 136.9oC
• PSA: 67.94000
• Density: 1.636g/cm3
• LogP: 2.59250
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-2-methoxy-4-methyl-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-methoxy-4-methyl-3-nitropyridine

There total 11 articles about 5-Bromo-2-methoxy-4-methyl-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methanol (67-56-1) + 2-amino-3-nitro-4-methyl-5-bromopyridine (100367-40-6) → 5-bromo-2-methoxy-4-methyl-3-nitropyridine (884495-14-1) + 2-hydroxy-5-bromo-4-methyl-3-nitropyridine (228410-90-0)

Guidance literature:

With tert.-butylnitrite; sulfuric acid; at 20 - 43 ℃; for 9.5h; Large scale;

DOI:10.1021/acs.oprd.7b00134

Reference yield: 25.0%

methanol (67-56-1) + 2-amino-3-nitro-4-methyl-5-bromopyridine (100367-40-6) → 5-bromo-2-methoxy-4-methyl-3-nitropyridine (884495-14-1) + 5-bromo-2-chloro-4-methyl-3-nitropyridine

Guidance literature:

With chloro-trimethyl-silane; sodium nitrite; at 15 - 25 ℃; for 18h; Large scale;

DOI:10.1021/acs.oprd.7b00134

Reference yield:

2-amino-5-bromo-4-methylpyridine (98198-48-2) → 5-bromo-2-methoxy-4-methyl-3-nitropyridine (884495-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid; nitric acid / water / 7 h / 25 - 33 °C / Large scale

2.1: sodium nitrite; chloro-trimethyl-silane / 18 h / 0 - 25 °C / Large scale

2.2: 8 h / 20 - 65 °C / Large scale

With chloro-trimethyl-silane; sulfuric acid; nitric acid; sodium nitrite; In water;

DOI:10.1021/acs.oprd.7b00134

upstream raw materials:

2-acetylamino-4-methylpyridine

N-(5-bromo-4-methylpyridin-2-yl)acetamide

2-amino-5-bromo-4-methylpyridine

methanol

Downstream raw materials:

5-bromo-4-methyl-2-(methyloxy)-3-pyridinamine

N-[5-bromo-4-methyl-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

2,4-difluoro-N-[4-methyl-2-(methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]benzenesulfonamide

N-[5-(2-amino-3-bromo-6-quinolinyl)-4-methyl-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Refernces