Technology Process of acoziborole
There total 9 articles about acoziborole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-amino-3,3-dimethyl-3H-benzo[c][1,2]oxaborol-1-ol hydrochloride;
With
triethylamine;
In
dichloromethane;
at 0 ℃;
2-trifluoromethyl-4-fluorobenzoyl chloride;
In
dichloromethane;
at 0 - 20 ℃;
- Guidance literature:
-
6-amino-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol;
With
potassium carbonate;
In
tetrahydrofuran;
at 20 ℃;
2-trifluoromethyl-4-fluorobenzoyl chloride;
In
tetrahydrofuran;
at 20 ℃;
for 24.1667h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene / 2 h / 50 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
2.2: 0.5 h / -78 - 20 °C
2.3: 0.5 h / 20 °C
3.1: trifluoroacetic acid; trifluoroacetic anhydride / 5 °C / Cooling with ice
3.2: 0 - 5 °C
4.1: hydrogen / 5% Pd(II)/C(eggshell) / tetrahydrofuran / 16 h
5.1: potassium carbonate / tetrahydrofuran / 20 °C
5.2: 24.17 h / 20 °C
With
n-butyllithium; hydrogen; potassium carbonate; trifluoroacetic acid; trifluoroacetic anhydride;
5% Pd(II)/C(eggshell);
In
tetrahydrofuran; hexane; toluene;