2-HYDROXY-6-METHYLPYRIDINE

Base Information

• Chemical Name: 2-HYDROXY-6-METHYLPYRIDINE
• CAS No.: 91914-07-7
• Molecular Formula: C₆H₇NO
• Molecular Weight: 109.128
• Mol file: 91914-07-7.mol

Synonyms:6-Methyl-2-pyridinol;6-Methyl-2H-pyridone;

Chemical Property of 2-HYDROXY-6-METHYLPYRIDINE

Chemical Property:

• Vapor Pressure: 0.000724mmHg at 25°C
• Melting Point: 157-159 °C(lit.)
• Refractive Index: 1.499
• Boiling Point: 281.231 °C at 760 mmHg
• Flash Point: 123.884 °C
• PSA: 33.12000
• Density: 1.053 g/cm³
• LogP: 1.09560

Purity/Quality:

98%min ^*data from raw suppliers

2-Hydroxy-6-methylpyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXY-6-METHYLPYRIDINE

There total 14 articles about 2-HYDROXY-6-METHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-methoxy-6-methyl-pyridine (63071-03-4) → 6-hydroxy-2-methylpyridine (3279-76-3,91914-07-7)

Guidance literature:

With hexamethyldisilathiane; sodium methylate; In various solvent(s); at 180 ℃; for 15h;

DOI:10.3987/COM-92-6197

Reference yield:

1-Benzyloxy-6-methyl-2-pyridone (128702-09-0) → 6-hydroxy-2-methylpyridine (3279-76-3,91914-07-7) + benzaldehyde (100-52-7) + benzyl alcohol (100-51-6,185532-71-2)

Guidance literature:

In cyclohexane; at 25 ℃; Quantum yield; Irradiation; var. temp., var. solvents, var. conc. of dibromomethane; deuterium isotope effect;

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 6-hydroxy-2-methylpyridine (3279-76-3,91914-07-7)

Guidance literature:

With sulfuric acid; sodium nitrite; Diazotization_.Erwaermen der Diazoniumsalz-Loesung;

upstream raw materials:

α-picoline

δ-caprolactam

2-Amino-6-methylpyridine

6-chloro-2-picoline

Downstream raw materials:

RuCl(CO)(C₅H₃CH₃NO)(P(C₆H₅)3)2

Rh(C₅H₃NOCH₃)(P(C₆H₅)3)2

[ReH(CH₃C₅H₃NO)2((C₆H₅)2PCH₂CH₂P(C₆H₅)2)]

2-(4-chloro-3-trifluoromethylphenoxy)-6-methyl-5-nitro-3-trimethylsilanylethynylpyridine

Refernces

• 1、 Shiao, Min-Jen,Ku, Wei-Shen,Hwu, Jih Ru. "Demethylation of methoxypyridines with sodium trimethylsilanethiolate". . p. 323 - 328. Retrieved 2007/10/02.
• 2、 Sakurai, Tadamitsu,Murakata, Yasukuni,Inoue, Hiroyasu. "The Photolysis of 1-Benzyloxy-2-pyridone and its Methyl Derivatives. Correlation with 1H NMR-derived Ground-state Conformation". . p. 499 - 503. Retrieved 2007/10/02.