3-Chloro-2-fluorobenzyl bromide

Base Information

• Chemical Name: 3-Chloro-2-fluorobenzyl bromide
• CAS No.: 85070-47-9
• Molecular Formula: C₇H₅BrClF
• Molecular Weight: 223.472
• Hs Code.: 29039990
• Mol file: 85070-47-9.mol

Synonyms:1-(Bromomethyl)-3-chloro-2-fluorobenzene;

Chemical Property of 3-Chloro-2-fluorobenzyl bromide

Chemical Property:

• Appearance/Colour: pale yellow low melting solid
• Vapor Pressure: 0.102mmHg at 25°C
• Melting Point: <35°C
• Refractive Index: 1.569
• Boiling Point: 230 °C at 760 mmHg
• Flash Point: 92.9 °C
• PSA: 0.00000
• Density: 1.654 g/cm³
• LogP: 3.37400
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Sensitive.: Lachrymatory
• Solubility.: Chloroform, DMSO, Methanol

Purity/Quality:

98% ^*data from raw suppliers

3-Chloro-2-fluorobenzyl Bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xn
• Statements: 34-36/37/38-52-22
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Chloro-2-fluorobenzyl Bromide (cas# 85070-47-9) is a compound useful in organic synthesis.

Technology Process of 3-Chloro-2-fluorobenzyl bromide

There total 2 articles about 3-Chloro-2-fluorobenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-chloro-2-fluorophenyl)methanol (261723-30-2) → 1-(bromomethyl)-3-chloro-2-fluorobenzene (85070-47-9)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

2-fluoro-3-chlorobenzaldehyde (85070-48-0) → 1-(bromomethyl)-3-chloro-2-fluorobenzene (85070-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2: phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; phosphorus tribromide; In tetrahydrofuran; dichloromethane;

Reference yield: 55.0%

2-Picolinic acid (98-98-6) + 1-(bromomethyl)-3-chloro-2-fluorobenzene (85070-47-9) → 2-(1,2-bis(3-chloro-2-fluorophenyl)ethyl)pyridine

Guidance literature:

With sodium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium dichloride; silver(l) oxide; In N,N-dimethyl acetamide; at 150 ℃; for 24h; Molecular sieve; Inert atmosphere;

DOI:10.1002/adsc.201400311

upstream raw materials:

(3-chloro-2-fluorophenyl)methanol

2-fluoro-3-chlorobenzaldehyde

Downstream raw materials:

C₁₅H₁₅ClFN₅OS₂

elvitegravir

(4-{5-[(3-chloro-2-fluorobenzyl)thio]-1,3,4-oxadiazol-2-yl}phenyl)methanol

Refernces