2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE

Base Information

• Chemical Name: 2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE
• CAS No.: 80466-56-4
• Molecular Formula: C4H4 N4 O4
• Molecular Weight: 172.1
• Hs Code.: 2933599090
• Mol file: 80466-56-4.mol

Synonyms:4(1H)-Pyrimidinone,2-amino-6-hydroxy-5-nitro- (9CI); 4,6-Pyrimidinediol, 2-amino-5-nitro- (6CI)

Chemical Property of 2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE

Chemical Property:

• Vapor Pressure: 1.52E-08mmHg at 25°C
• Melting Point: >400°C
• Boiling Point: 445.3oC at 760 mmHg
• PKA: 2.69±0.10(Predicted)
• Flash Point: 223.1oC
• PSA: 138.08000
• Density: 2.3g/cm3
• LogP: 0.48260
• Storage Temp.: Refrigerator
• Solubility.: Readily Soluble in Aqueous Potassium Hydroxide

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-4,6-dihydroxy-5-nitropyrimidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE

There total 7 articles about 2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-amino-6-hydroxy-pyrimidin-4(3H)-one (56-09-7) → 2-amino-6-hydroxy-5-nitropyrimidin-4(3H)-one (80466-56-4)

Guidance literature:

With sulfuric acid; potassium nitrate; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2009.08.029

Reference yield: 30.0%

1-amino-4,4-diethoxypentan-3-ol (114113-83-6) + 2-amino-6-chloro-5-nitro-3H-pyrimidine-4-one (1007-99-4) → 2-amino-6-(4,4-diethoxy-3-hydroxypentylamino)-5-nitropyrimidin-4(3H)-one (114113-85-8) + 2-amino-6-hydroxy-5-nitropyrimidin-4(3H)-one (80466-56-4)

Guidance literature:

With potassium acetate; In ethanol; for 1h; Heating;

Reference yield: 29.0%

diethyl nitromalonate (603-67-8) + guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) → 2-amino-5-nitropyrimidine-4,6-diol (80466-56-4)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.5h; Heating;

upstream raw materials:

diethyl nitromalonate

guanidine hydrogen carbonate

2-aminopyrimidine-4,6-diol

2-amino-6-amino-5-nitropyrimidin-4(3H)-one

Downstream raw materials:

2-amino-4,5,6-trichloropyrimidine

2,5-diamino-4,6-dihydroxypyrimidine hydrochloride

Refernces

• 1、 Lopez, Sergio,McCabe, Thomas,Stanley McElhinney,McMurry, T. Brian H.,Rozas, Isabel. "Syntheses of 2-amino-4,6-dichloro-5-nitropyrimidine and 2-amino-4,5,6-trichloropyrimidine: an unusual aromatic substitution". scheme or table. p. 6022 - 6024. Retrieved 2010/03/03.
• 2、 Boyle, Peter H.,Hughes, Enid M.,Khattab, Hassan A.,Lockhart, Ronan J.. "Synthesis of a Naturally Occurring Dihydrohomopteridine Insect Metabolite, 6-Acetyl-2-amino-7,8-dihydro-9H-pyrimidodiazepin-4(3H)-one". . p. 2071 - 2077. Retrieved 2007/10/02.