4-CHLORO-M-XYLENE

Base Information

• Chemical Name: 4-CHLORO-M-XYLENE
• CAS No.: 95-66-9
• Molecular Formula: C8H9Cl
• Molecular Weight: 140.612
• Hs Code.: 2903999090
• Mol file: 95-66-9.mol

Synonyms:4-Chloro-m-xylene;4-Chloro-1,3-dimethylbenzene;2,4-Dimethylchlorobenzene;1-Chloro-2,4-dimethylbenzene;1,3-Dimethyl-4-chlorobenzene;m-Xylene,4-chloro- (7CI,8CI);

Chemical Property of 4-CHLORO-M-XYLENE

Chemical Property:

• Vapor Pressure: 0.866mmHg at 25°C
• Melting Point: -32 °C
• Refractive Index: 1.521
• Boiling Point: 187.5 °C at 760 mmHg
• Flash Point: 62.1 °C
• PSA: 0.00000
• Density: 1.049 g/cm³
• LogP: 2.95680
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-m-xylene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-m-xylene is used as a reagent in the synthesis of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists.

Technology Process of 4-CHLORO-M-XYLENE

There total 22 articles about 4-CHLORO-M-XYLENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

m-xylene (108-38-3,104809-90-7) → 2,4-dimethylchlorobenzene (95-66-9)

Guidance literature:

With calcium hypochlorite; In water; acetic acid; acetone; at 0 ℃; for 1h;

Reference yield: 45.0%

chlorocarbonic acid-(2,4-dimethyl-phenyl ester) (35709-99-0) → 2,4-dimethylchlorobenzene (95-66-9)

Guidance literature:

With aluminium trichloride; In various solvent(s); at 200 ℃; for 3.5h;

DOI:10.1021/jo9716486

Reference yield: 5.8%

2,4-dimethylbenzenediazonium tetrafluoroborate → 2,4-dimethylchlorobenzene (95-66-9) + 1-bromo-2,4-dimethylbenzene (583-70-0)

Guidance literature:

With sodium bromide; sodium chloride; In methanol; at 21 - 23.5 ℃; Product distribution; Kinetics; investigations of thermal dediazoniation in various solvents as a function of viscosity; the reaction are diffusion controlled;

DOI:10.1016/S0040-4039(00)70691-5

upstream raw materials:

2,4-dimethylbenzenesulfonic acid

2-chloro-5-methylbenzyl chloride

acetic acid-(2,4,6,N-tetrachloro-anilide)

acetic acid

Downstream raw materials:

(2,4-dimethylphenyl)(trimethyl)silan

4-chloro-3-methylbenzoic acid

4-chloroisophthalic acid

4-chloro-1,3-bis-(trichloromethyl)-benzene

Refernces

• 1、 -. "A 3,5-dimethyl aniline method for the preparation of". Paragraph 0022; 0035. . Retrieved 2016/10/08.
• 2、 Mo, Fanyang,Yan, Jerry Mingtao,Qiu, Di,Li, Fei,Zhang, Yan,Wang, Jianbo. "Gold-catalyzed halogenation of aromatics by N-halosuccinimides". supporting information; scheme or table. p. 2028 - 2032. Retrieved 2010/06/17.