2-chloro-5-methylbenzyl chloride

Base Information

• Chemical Name: 2-chloro-5-methylbenzyl chloride
• CAS No.: 34896-68-9
• Molecular Formula: C₈H₈Cl₂
• Molecular Weight: 175.058
• Mol file: 34896-68-9.mol

Synonyms:2-chloro-5-methylbenzyl chloride

Chemical Property of 2-chloro-5-methylbenzyl chloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-methylbenzylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Chloro-2-(chloromethyl)-4-methylbenzene is used as a reactant in the preparation of indazolones as modulators of TNF signaling.

Technology Process of 2-chloro-5-methylbenzyl chloride

There total 3 articles about 2-chloro-5-methylbenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + para-chlorotoluene (106-43-4) → 2-chloro-5-methylbenzyl chloride (34896-68-9)

Guidance literature:

With hydrogenchloride; zinc(II) chloride; weiteres Edukt: Chlorwasserstoff;

DOI:10.1021/ja01520a032

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + para-chlorotoluene (106-43-4) → 2-chloro-5-methylbenzyl chloride (34896-68-9) + 1-chloro-2,5-bis-chloromethyl-4-methyl-benzene (56403-25-9)

Guidance literature:

With hydrogenchloride; zinc(II) chloride;

DOI:10.1021/ja01520a032 DOI:10.1021/jo00909a019

Reference yield:

→ 2-chloro-5-methylbenzyl chloride (34896-68-9)

Guidance literature:

With 1,3,5-trichloro-2,4,6-triazine; In dimethyl sulfoxide; at 0 - 40 ℃; for 0.75h;

upstream raw materials:

formaldehyd

para-chlorotoluene

Downstream raw materials:

2,4-dimethylchlorobenzene

bis-(2-chloro-5-methyl-phenyl)-methane

Refernces