4-butanoyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate

Base Information

• Chemical Name: 4-butanoyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate
• CAS No.: 171284-24-5
• Molecular Formula: C₃₁H₃₇N₁₀O₁₂P
• Molecular Weight: 772.668
• Mol file: 171284-24-5.mol

Synonyms:4-butanoyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate

Chemical Property of 4-butanoyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-butanoyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate

There total 1 articles about 4-butanoyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) + 4-butanoyloxybenzyl bis(N,N-diisopropyl)phosphoramidite (171284-21-2) → 4-butanoyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate (171284-24-5)

Guidance literature:

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; Yield given. Multistep reaction; 1.) MeCN, 30 min, 2.) - 40 deg C - room temperature; room temperature, 5 min;

DOI:10.1080/15257779508009491

Reference yield:

4-butanoyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate (171284-24-5) → 3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) + 3'-azido-2',3'-dideoxythymidine monophosphate (29706-85-2) + bis(3'-azido-3'-deoxy-5'-thymidinyl) phosphate (121135-54-4)

Guidance literature:

In water-d2; for 120h; Product distribution; RPMI 1640 media, fetal claf serum; chemical and biochemical hydrolysis of triester at various conditions; 31P NMR monitoring;

DOI:10.1080/15257779508009491

upstream raw materials:

3'-azido-2',3'-deoxythymidine

4-butanoyloxybenzyl bis(N,N-diisopropyl)phosphoramidite

Downstream raw materials:

3'-azido-2',3'-deoxythymidine

3'-azido-2',3'-dideoxythymidine monophosphate

bis(3'-azido-3'-deoxy-5'-thymidinyl) phosphate

Refernces