2-Bromo-5-trifluoromethylphenol

Base Information

• Chemical Name: 2-Bromo-5-trifluoromethylphenol
• CAS No.: 402-05-1
• Molecular Formula: C7H4BrF3O
• Molecular Weight: 241.007
• Hs Code.: 2908199090
• Mol file: 402-05-1.mol

Synonyms:2-Bromo-5-trifluoromethylphenol;m-Cresol,6-bromo-a,a,a-trifluoro- (8CI);

Chemical Property of 2-Bromo-5-trifluoromethylphenol

Chemical Property:

• Vapor Pressure: 0.0826mmHg at 25°C
• Refractive Index: 1.505
• Boiling Point: 219 °C at 760 mmHg
• PKA: 7.43±0.10(Predicted)
• Flash Point: 86.3 °C
• PSA: 20.23000
• Density: 1.752 g/cm³
• LogP: 3.17350
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-5-trifluoromethylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-3-(trifluoromethyl)phenol is used as a reactant in the synthesis of benzimidazolone and benzothiazolone compounds as AMPA receptor modulators.

Technology Process of 2-Bromo-5-trifluoromethylphenol

There total 2 articles about 2-Bromo-5-trifluoromethylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

→ 2-bromo-5-(trifluoromethyl)phenol (402-05-1)

Guidance literature:

With bromine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

3-Trifluoromethylphenol (98-17-9) → 2-bromo-5-(trifluoromethyl)phenol (402-05-1)

Guidance literature:

With tetrachloromethane; bromine;

DOI:10.1021/ja01147a139 DOI:10.1021/jo01144a011

Reference yield: 97.0%

2-bromo-5-(trifluoromethyl)phenol (402-05-1) + 2-Bromoethyl methyl ether (6482-24-2) → 1-bromo-2-(2-methoxyethoxy)-4-(trifluoromethyl)benzene

Guidance literature:

With caesium carbonate; In acetonitrile; at 80 ℃; for 16h;

upstream raw materials:

3-Trifluoromethylphenol

Downstream raw materials:

1-bromo-2-methoxy-4-(trifluoromethyl)benzene

2-methoxy-4-(trifluoromethyl)-benzoic acid

tert-butyl {3-[2-bromo-5-(trifluoromethyl)phenoxy]propyl}carbamate

1-benzyl-3-{[2-bromo-5-(trifluoromethyl)phenoxy]methyl}-2,5-dihydro-1H-pyrrole

Refernces

• 1、 -. "Benzofurylpiperazine serotonin agonists". . . Retrieved 2008/06/13.