(R)-2-Amino-3-(4-ethylphenyl)propanoic acid

Base Information

• Chemical Name: (R)-2-Amino-3-(4-ethylphenyl)propanoic acid
• CAS No.: 721385-17-7
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Hs Code.: 2922498590
• Mol file: 721385-17-7.mol

Synonyms:4-ETHYL-D-PHENYLALANINE; D-4-ETHYLPHENYLALANINE; D-Phenylalanine,4-ethyl; (R)-2-amino-3-(4-ethylphenyl)propanoic acid;

Chemical Property of (R)-2-Amino-3-(4-ethylphenyl)propanoic acid

Chemical Property:

• Vapor Pressure: 4.72E-05mmHg at 25°C
• Refractive Index: 1.559
• Boiling Point: 335.4°C at 760 mmHg
• PKA: 2.23±0.10(Predicted)
• Flash Point: 156.7°C
• PSA: 63.32000
• Density: 1.135g/cm³
• LogP: 1.90370

Purity/Quality:

90.0%Min ^*data from raw suppliers

4-?Ethyl-D-?phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-?Ethyl-D-?phenylalanine is a reagent used in pharmaceutical synthesis. D-Phenylalanine (P319410) derivative, used in the synthesis of Schaeffer’s acid analogues as important structures in tuberculostatic design.

Technology Process of (R)-2-Amino-3-(4-ethylphenyl)propanoic acid

There total 13 articles about (R)-2-Amino-3-(4-ethylphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C11H12O3 → D-p-ethylphenylalanine (721385-17-7)

Guidance literature:

With D-glucose; nicotinamide adenine dinucleotide phosphate; ammonium chloride; In methanol; at 20 ℃; for 24h; pH=9; enantioselective reaction; Microbiological reaction;

DOI:10.1002/adsc.201600682

Reference yield:

4-ethyl cinnamic acid (120680-98-0) → 3-amino-3-(4-ethyl-phenyl)-propionic acid + L-p-ethylphenylalanine (4313-70-6,721385-17-7)

Guidance literature:

With carbon dioxide; Taxus chinensis phenylalanine aminomutase; ammonia; In water; pH=10; optical yield given as %ee; enantioselective reaction; Kinetics; Enzymatic reaction;

DOI:10.1021/jo901833y

Reference yield:

→ L-p-ethylphenylalanine (4313-70-6,721385-17-7)

Guidance literature:

upstream raw materials:

ethylbenzene

4-ethylbenzyl bromide

4-ethyl cinnamic acid

4-ethylbenzylaldehyde

Downstream raw materials:

(S)-3-(4-Ethyl-phenyl)-2-(2-nitro-phenylsulfanylamino)-propionic acid

Refernces

• 1、 Parmeggiani, Fabio,Ahmed, Syed T.,Thompson, Matthew P.,Weise, Nicholas J.,Galman, James L.,Gahloth, Deepankar,Dunstan, Mark S.,Leys, David,Turner, Nicholas J.. "Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase". . p. 3298 - 3306. Retrieved 2016/10/20.
• 2、 -. "Analogues of 8-D-homoarginine vasopressin". . . Retrieved 2008/06/13.