3-Amino-4-hydroxybenzoic acid hydrochloride

Base Information

• Chemical Name: 3-Amino-4-hydroxybenzoic acid hydrochloride
• CAS No.: 1571-65-9
• Molecular Formula: C7H8ClNO3
• Molecular Weight: 189.598
• Hs Code.: 2922509090
• Mol file: 1571-65-9.mol

Synonyms:Benzoicacid, 3-amino-4-hydroxy-, hydrochloride (7CI,8CI,9CI);3-Amino-4-hydroxybenzoicacid hydrochloride;

Chemical Property of 3-Amino-4-hydroxybenzoic acid hydrochloride

Chemical Property:

• Vapor Pressure: 3.23E-07mmHg at 25°C
• Melting Point: 275 °C (decomp)
• Boiling Point: 403 °C at 760 mmHg
• Flash Point: 197.5 °C
• PSA: 83.55000
• LogP: 2.05580

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-4-hydroxybenzoicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-4-hydroxybenzoic acid hydrochloride

There total 4 articles about 3-Amino-4-hydroxybenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

methyl (4-hydroxy-3-nitro)benzoate (99-42-3) → 3-amino-4-hydroxybenzoic acid hydrochloride (1571-65-9)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; In water; for 5h; Reflux;

Reference yield:

3-chloro-4-nitrobenzoic acid (39608-47-4) → 3-amino-4-hydroxybenzoic acid hydrochloride (1571-65-9)

Guidance literature:

With potassium hydroxide; In water;

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 3-amino-4-hydroxybenzoic acid hydrochloride (1571-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; nitric acid / 2 h / 5 - 10 °C

2: tin(II) chloride dihdyrate; hydrogenchloride / water / 5 h / Reflux

With hydrogenchloride; tin(II) chloride dihdyrate; nitric acid; acetic acid; In water;

upstream raw materials:

3-chloro-4-nitrobenzoic acid

methyl 4-hydroxylbenzoate

methyl (4-hydroxy-3-nitro)benzoate

Refernces

• 1、 -. "Preparation of 3-amino-4-hydroxybenzoic acids". . . Retrieved 2008/06/13.