3-Chloro-4-nitrobenzoic acid

Base Information

• Chemical Name: 3-Chloro-4-nitrobenzoic acid
• CAS No.: 39608-47-4
• Molecular Formula: C7H4NO4Cl
• Molecular Weight: 201.566
• Hs Code.: 2916399090
• Mol file: 39608-47-4.mol

Synonyms:3-CHLORO-4-NITROBENZOIC ACID

Chemical Property of 3-Chloro-4-nitrobenzoic acid

Chemical Property:

• Melting Point: 178-180 °C
• Boiling Point: 382.7 °C at 760 mmHg
• PKA: 3.05±0.10(Predicted)
• Flash Point: 185.2 °C
• PSA: 83.12000
• Density: 1.602 g/cm³
• LogP: 2.46960
• Storage Temp.: Keep Cold

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-nitrobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-4-nitrobenzoic acid

There total 5 articles about 3-Chloro-4-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-chloro-4-methyl-1-nitrobenzene (38939-88-7) → 3-chloro-4-nitrobenzoic acid (39608-47-4)

Guidance literature:

With pyridine; potassium permanganate; In water; at 90 ℃;

Reference yield: 40.0%

1-chloro-3-methylbenzene (108-41-8) → 3-chloro-4-nitrobenzoic acid (39608-47-4)

Guidance literature:

1-chloro-3-methylbenzene; With sulfuric acid; nitric acid; at 15 - 22 ℃;

With potassium dichromate; sulfuric acid; for 2h; Heating;

DOI:10.1016/S0968-0896(03)00497-8

Reference yield:

→ 3-chloro-4-nitrobenzoic acid (39608-47-4)

Guidance literature:

With hydrogenchloride; ethanol;

DOI:10.1002/hlca.19510340515

upstream raw materials:

2-chloro-4-methyl-1-nitrobenzene

1-chloro-3-methylbenzene

3-chloro-4-nitroaniline

Downstream raw materials:

3-chloro-4-[(7-cyclopentyI-8-ethyI-10-methyl-9-oxo-3,5,7,8,10-pentazabicycIo[4.4.0]deca-1,3,5-trien-4-yl)amino]-N-(1-methyI-4-piperidyl)benzamide

4-amino-3-chloro-N-(1-methyl-4-piperidyl)benzamide

Refernces

• 1、 Navarrete-Vazquez, Gabriel,Yepez, Lilian,Hernandez-Campos, Alicia,Tapia, Amparo,Hernandez-Luis, Francisco,Cedillo, Roberto,Gonzalez, Jose,Martinez-Fernandez, Antonio,Martinez-Grueiro, Mercedes,Castillo, Rafael. "Synthesis and antiparasitic activity of Albendazole and Mebendazole analogues". . p. 4615 - 4622. Retrieved 2007/10/03.