4-Aminopiperidine

Base Information

• Chemical Name: 4-Aminopiperidine
• CAS No.: 13035-19-3
• Molecular Formula: C5H12N2
• Molecular Weight: 100.164
• Hs Code.: 29333990
• European Community (EC) Number: 603-408-2,700-302-9,694-568-2
• DSSTox Substance ID: DTXSID80329842
• Nikkaji Number: J81.534I
• Wikidata: Q72441026
• ChEMBL ID: CHEMBL174570
• Mol file: 13035-19-3.mol

Synonyms:4-amino-piperidine;4-aminopiperidine

Chemical Property of 4-Aminopiperidine

Chemical Property:

• Vapor Pressure: 2.57mmHg at 25°C
• Melting Point: 25 °C
• Refractive Index: n20/D 1.4910(lit.)
• Boiling Point: 158.9 °C at 760 mmHg
• PKA: 10.37±0.20(Predicted)
• Flash Point: 53.4 °C
• PSA: 38.05000
• Density: 0.91 g/cm³
• LogP: 0.72620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Hygroscopic
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 100.100048391
• Heavy Atom Count: 7
• Complexity: 48

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Aminopiperidine >96.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C,Xi
• Statements: 10-34
• Safety Statements: 16-23-26-36/37/39-45-6

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1N
• Uses: Reactant for synthesis of 4-Aminopiperidine: Cdk5/p25 kinase inhibitors Antimalarials Selective cyclin-dependent kinase 4/6 inhibitors IKKβ inhibitors Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation Human and murine soluble epoxide hydrolase inhibitors Reactant for synthesis of:Cdk5/p25 kinase inhibitorsAntimalarialsSelective cyclin-dependent kinase 4/6 inhibitorsIKKβ inhibitorsOrally bioavailable P2Y12 antagonists for inhibition of platelet aggregationHuman and murine soluble epoxide hydrolase inhibitors

Technology Process of 4-Aminopiperidine

There total 16 articles about 4-Aminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-aminopyridine (504-24-5) + ethanol (64-17-5) → piperidine (110-89-4) + 4-aminopiperidine (13035-19-3) + ammonia (7664-41-7)

Guidance literature:

Reference yield:

4-aminopyridine (504-24-5) + sulfuric acid (7664-93-9) → piperidine (110-89-4) + 4-aminopiperidine (13035-19-3) + ammonia (7664-41-7)

Guidance literature:

bei der elektrolytischen Reduktion;

Reference yield:

4-aminopyridine (504-24-5) → 4-aminopiperidine (13035-19-3) + dipiperidin-4-ylamine (508201-22-7)

Guidance literature:

With hydrogen; Rh on carbon; at 160 ℃; for 3h; under 52505.3 Torr;

DOI:10.1039/b718209k

upstream raw materials:

4-aminopyridine

N-(1-acetyl-[4]piperidyl)-acetamide

piperidine-4-carboxylic acid hydrazide; dihydrochloride

4-amino-1-benzylpiperidine

Downstream raw materials:

4-{1-[4-(4-amino-piperidin-1-ylmethyl)-benzyl]-5,6-dichloro-1H-benzoimidazol-2-yl}-piperidine-1-carboxylic acid tert-butyl ester

4-{5,6-dichloro-1-[4-(piperidin-4-ylaminomethyl)-benzyl]-1H-benzoimidazol-2-yl}-piperidine-1-carboxylic acid tert-butyl ester

N-(1-{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-piperidin-4-yl)-formamide

1-(tert-butoxycarbonyl)-4-aminopiperidine

Refernces

• 1、 Cui, Yi,Kwok, Samantha,Bucholtz, Andrew,Davis, Boyd,Whitney, Ralph A.,Jessop, Philip G.. "The effect of substitution on the utility of piperidines and octahydroindoles for reversible hydrogen storage". . p. 1027 - 1037. Retrieved 2008/12/20.
• 2、 Lewin, Anita H.,Fudala, Louise,Navarro, Hernan,Zhou, Li-Ming,Popik, Piotr,Faynsteyn, Alexander,Skolnick, Phil. "Molecular features associated with polyamine modulation of NMDA receptors". . p. 988 - 995. Retrieved 2007/10/03.