5-Bromo-6-chloropyridine-3-sulfonyl chloride

Base Information

• Chemical Name: 5-Bromo-6-chloropyridine-3-sulfonyl chloride
• CAS No.: 216394-05-7
• Molecular Formula: C5H2BrCl2NO2S
• Molecular Weight: 290.952
• Hs Code.: 2933399090
• European Community (EC) Number: 674-555-8
• DSSTox Substance ID: DTXSID80383146
• Wikidata: Q72453438
• Mol file: 216394-05-7.mol

Synonyms:5-bromo-6-chloropyridine-3-sulfonyl chloride;216394-05-7;3-bromo-2-chloropyridine-5-sulfonyl chloride;3-BROMO-2-CHLOROPYRIDINE-5-SULPHONYL CHLORIDE;5-bromo-6-chloro-pyridine-3-sulfonyl Chloride;MFCD01318107;5-bromo-6-chloro-3-pyridinesulfonyl chloride;C5H2BrCl2NO2S;5-Bromo-6-chloropyridine-3-sulfonylchloride;5-Bromo-6-chloro-3-pyridine sulfonyl chloride;3-Pyridinesulfonyl chloride, 5-bromo-6-chloro-;SCHEMBL516599;DTXSID80383146;TURGMVYIESHZBE-UHFFFAOYSA-N;AC2052;STL227726;AKOS000267002;AKOS025116738;PB48425;AS-76596;SY042749;3-bromo-2-chloropyridine-5-sulphonylchloride;BB 0260008;FT-0615138;EN300-90116;A815562;5-bromanyl-6-chloranyl-pyridine-3-sulfonyl chloride;F3099-7187;Z1171217824;3-Bromo-2-chloropyridine-5-sulfonyl chloride, AldrichCPR

Chemical Property of 5-Bromo-6-chloropyridine-3-sulfonyl chloride

Chemical Property:

• Appearance/Colour: Pale Yellow Solid
• Vapor Pressure: 7.62E-05mmHg at 25°C
• Melting Point: 71-73°C
• Refractive Index: 1.604
• Boiling Point: 352.8 °C at 760 mmHg
• PKA: -6.06±0.10(Predicted)
• Flash Point: 167.2 °C
• PSA: 55.41000
• Density: 1.973g/cm³
• LogP: 3.50580
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Solubility.: Dichloromethane
• Water Solubility.: Reacts with water. Soluble in dichloromethane.
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 288.83667
• Heavy Atom Count: 12
• Complexity: 253

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-6-chloropyridine-3-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Br)Cl)S(=O)(=O)Cl
• Uses: 3-Bromo-2-chloropyridine-5-sulfonyl chloride is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff field.

Technology Process of 5-Bromo-6-chloropyridine-3-sulfonyl chloride

There total 7 articles about 5-Bromo-6-chloropyridine-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Amino-3-bromopyridine-5-sulphonic Acid (247582-62-3) → 5-bromo-6-chloropyridine-3-sulfonyl chloride (216394-05-7)

Guidance literature:

2-Amino-3-bromopyridine-5-sulphonic Acid; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With phosphorus pentachloride; trichlorophosphate; at 75 - 125 ℃;

Reference yield: 91.0%

→ 5-bromo-6-chloropyridine-3-sulfonyl chloride (216394-05-7)

Guidance literature:

Reference yield: 87.0%

1-methyl-piperazine (109-01-3) → 1-[(5-bromo-6-chloropyridin-3-yl)sulfonyl]-4-methylpiperazine + 5-bromo-6-chloropyridine-3-sulfonyl chloride (216394-05-7)

Guidance literature:

upstream raw materials:

1-methyl-piperazine

2-Amino-3-bromopyridine-5-sulphonic Acid

2-aminopyridine

pyridine-2-amino-5-sulphonic acid

Downstream raw materials:

2-Ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridine-3-carboxylic Acid

4-[2-(2,4-difluorophenoxy)-5-(ethylsulfonyl)pyridin-3-yl]-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

4-(2-chloro-5-(ethylsulfonyl)pyridin-3-yl)-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one

2-amino-5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-3-pyridinecarbonitrile

Refernces

• 1、 Crosignani, Stefano,Prêtre, Adeline,Jorand-Lebrun, Catherine,Fraboulet, Ga?le,Seenisamy, Jeyaprakashnarayanan,Augustine, John Kallikat,Missotten, Marc,Humbert, Yves,Cleva, Christophe,Abla, Nada,Daff, Hamina,Schott, Olivier,Schneider, Manfred,Burgat-Charvillon, Fabienne,Rivron, Delphine,Hamernig, Ingrid,Arrighi, Jean-Fran?ois,Gaudet, Marilène,Zimmerli, Simone C.,Juillard, Pierre,Johnson, Zoe. "Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases". supporting information; experimental part. p. 7299 - 7317. Retrieved 2011/12/15.
• 2、 -. "Treatment of neuropathy". . . Retrieved 2008/06/13.