6-Amino-5-bromopyridine-3-sulfonic acid

Base Information

• Chemical Name: 6-Amino-5-bromopyridine-3-sulfonic acid
• CAS No.: 247582-62-3
• Molecular Formula: C₅H₅BrN₂O₃S
• Molecular Weight: 253.076
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20364494
• Mol file: 247582-62-3.mol

Synonyms:6-amino-5-bromopyridine-3-sulfonic acid;247582-62-3;2-amino-3-bromopyridine-5-sulfonic acid;3-Pyridinesulfonic acid, 6-amino-5-bromo-;6-amino-5-bromopyridine-3-sulphonic acid;MFCD03085772;C5H5BrN2O3S;6-Amino-5-bromo-3-pyridine sulfonic acid;AF-399/40768852;SCHEMBL1370997;DTXSID20364494;STL227727;AKOS000267003;PS-7446;FT-0620920;A817479;SR-01000012066;SR-01000012066-1;F1371-0173

Chemical Property of 6-Amino-5-bromopyridine-3-sulfonic acid

Chemical Property:

• Melting Point: >250 °C
• Refractive Index: 1.669
• PKA: -1.98±0.50(Predicted)
• PSA: 101.66000
• Density: 2.042 g/cm³
• LogP: 2.33500
• Storage Temp.: Refrigerator
• Solubility.: Sparingly soluble in DMSO and Water
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 251.92043
• Heavy Atom Count: 12
• Complexity: 250

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-3-bromopyridine-5-sulfonic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Br)N)S(=O)(=O)O

Technology Process of 6-Amino-5-bromopyridine-3-sulfonic acid

There total 4 articles about 6-Amino-5-bromopyridine-3-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ pyridine-2-amino-5-sulphonic acid (16250-08-1) + 2-Amino-3-bromopyridine-5-sulphonic Acid (247582-62-3)

Guidance literature:

Reference yield:

pyridine-2-amino-5-sulphonic acid (16250-08-1) → 2-Amino-3-bromopyridine-5-sulphonic Acid (247582-62-3)

Guidance literature:

With water; bromine;

Reference yield:

2-aminopyridine (504-29-0) → 2-Amino-3-bromopyridine-5-sulphonic Acid (247582-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; sulfur trioxide / 4 h / 140 °C

2: bromine / water / 1 h / Reflux

With sulfuric acid; sulfur trioxide; bromine; In water;

DOI:10.1016/j.bmc.2011.10.022

upstream raw materials:

pyridine-2-amino-5-sulphonic acid

2-aminopyridine

Downstream raw materials:

2-Ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridine-3-carboxylic Acid

5-bromo-6-chloropyridine-3-sulfonyl chloride

Refernces

• 1、 -. "Treatment of neuropathy". . . Retrieved 2008/06/13.
• 2、 -. "Treatments for female sexual dysfunction and methods for identifying compounds useful for treating female sexual dysfunction". . . Retrieved 2008/06/13.