5-Chloro-2-methoxybenzenemethanamine

Base Information

• Chemical Name: 5-Chloro-2-methoxybenzenemethanamine
• CAS No.: 896127-80-3
• Molecular Formula: C₈H₁₀ClNO
• Molecular Weight: 171.626
• Hs Code.: 2922299090
• Mol file: 896127-80-3.mol

Synonyms:benzenemethanamine, 5-chloro-2-methoxy-;1-(5-chloro-2-methoxyphenyl)methanamine;5-Chloro-2-methoxybenzenemethanamine;

Chemical Property of 5-Chloro-2-methoxybenzenemethanamine

Chemical Property:

• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 252.785 °C at 760 mmHg
• Flash Point: 106.681 °C
• PSA: 35.25000
• Density: 1.181 g/cm³
• LogP: 2.50760

Purity/Quality:

98%Min ^*data from raw suppliers

(4-chloro-2-methoxyphenyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-2-methoxybenzenemethanamine

There total 5 articles about 5-Chloro-2-methoxybenzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(azidomethyl)-4-chloro-2-methoxybenzene (896127-79-0) → (4-chloro-2-methoxyphenyl)methanamine (896127-80-3)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

(4-chloro-2-methoxy-phenyl)methanol (90296-27-8) → (4-chloro-2-methoxyphenyl)methanamine (896127-80-3)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 6 h / 20 °C / Inert atmosphere

2: sodium azide / water; N,N-dimethyl-formamide / 20 h / 20 °C

3: triphenylphosphine / tetrahydrofuran; water / 72 h / 20 °C

With thionyl chloride; sodium azide; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

methyl 4-chloro-2-methoxybenzoate (78955-90-5) → (4-chloro-2-methoxyphenyl)methanamine (896127-80-3)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 6 h / 20 °C / Inert atmosphere

3: sodium azide / water; N,N-dimethyl-formamide / 20 h / 20 °C

4: triphenylphosphine / tetrahydrofuran; water / 72 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sodium azide; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

1-(azidomethyl)-4-chloro-2-methoxybenzene

(4-chloro-2-methoxy-phenyl)methanol

methyl 4-chloro-2-methoxybenzoate

4-chloro-1-(chloromethyl)-2-methoxybenzene

Refernces

• 1、 -. "3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES". Page/Page column 100. . Retrieved 2008/12/04.