6,7-Dimethoxy-2-tetralone

Base Information

• Chemical Name: 6,7-Dimethoxy-2-tetralone
• CAS No.: 2472-13-1
• Molecular Formula: C12H14O3
• Molecular Weight: 206.241
• Hs Code.: 2914509090
• Mol file: 2472-13-1.mol

Synonyms:3,4-Dihydro-6,7-dimethoxy-2(1H)-naphthalenone;6,7-Dimethoxy-3,4-dihydro-1H-naphthalen-2-one;6,7-Dimethoxy-b-tetralone;

Chemical Property of 6,7-Dimethoxy-2-tetralone

Chemical Property:

• Vapor Pressure: 5.17E-05mmHg at 25°C
• Melting Point: 87-89 °C(lit.)
• Refractive Index: 1.537
• Boiling Point: 348 °C at 760 mmHg
• Flash Point: 155.5 °C
• PSA: 35.53000
• Density: 1.14 g/cm³
• LogP: 1.76160

Purity/Quality:

99% ^*data from raw suppliers

6,7-Dimethoxy-3,4-dihydro-1H-naphthalen-2-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,7-Dimethoxy-2-tetralone

There total 2 articles about 6,7-Dimethoxy-2-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

tert-Butyl-[3-(3,4-dimethoxy-phenyl)-1-methylene-propoxy]-dimethyl-silane (153993-01-2) → 6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-one (2472-13-1) + 4-(3,4-dimethoxy-phenyl)-butan-2-one (6302-60-9)

Guidance literature:

With naphthalene-1,4-dicarbonitrile; In water; acetonitrile; for 3h; Irradiation;

DOI:10.1016/0040-4039(93)88123-Z

Reference yield:

ethene (74-85-1) + 3,4-dimethoxyphenylacetyl chloride (10313-60-7) → 6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-one (2472-13-1) + 1-(3,4-dimethoxyphenyl)-4-chloro-2-butanone

Guidance literature:

With aluminium trichloride; In dichloromethane; for 4h; Title compound not separated from byproducts; Ambient temperature;

DOI:10.1021/jm00353a016

Reference yield: 92.0%

2-(4-phenyl-piperazin-1-yl)-ethylamine (21091-61-2) + 6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-one (2472-13-1) → 6,7-dimethoxy-N-[2-(4-phenylpiperazin-1-yl)ethyl]-1,2,3,4-tetrahydronaphthalen-2-amine (1003565-56-7)

Guidance literature:

2-(4-phenyl-piperazin-1-yl)-ethylamine; 6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-one; With acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 0.333333h;

With sodium tris(acetoxy)borohydride; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 12h; Further stages.;

DOI:10.1021/jm070860r

upstream raw materials:

ethene

3,4-dimethoxyphenylacetyl chloride

tert-Butyl-[3-(3,4-dimethoxy-phenyl)-1-methylene-propoxy]-dimethyl-silane

Downstream raw materials:

N-(3,3-diphenylpropyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-naphthalenamine

3',4'-dihydro-6',7'-dimethoxyspiro-2,5-dione

N-benzyl-6,7-dimethoxy-3,4-dihydronaphthalen-2-amine

2-benzylamino-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene

Refernces

• 1、 Pandey,Krishna,Girija,Karthikeyan. "Intramolecular nucleophilic addition of silylenol ether to photosensitized electron transfer (PET) generated arene radical cations: A novel non-reagent based carboannulation reaction". . p. 6631 - 6634. Retrieved 2007/10/02.