8-Hydroxy-2-tetralone

Base Information

• Chemical Name: 8-Hydroxy-2-tetralone
• CAS No.: 53568-05-1
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.188
• Hs Code.: 2914501900
• Mol file: 53568-05-1.mol

Synonyms:3,4-Dihydro-8-hydroxy-2(1H)-naphthalenone;8-Hydroxy-2-tetralone;8-Hydroxy-3,4-dihydronaphthalen-2(1H)-one;

Chemical Property of 8-Hydroxy-2-tetralone

Chemical Property:

• Vapor Pressure: 6.96E-05mmHg at 25°C
• Refractive Index: 1.602
• Boiling Point: 333.6°Cat760mmHg
• Flash Point: 141.8°C
• PSA: 37.30000
• Density: 1.236g/cm³
• LogP: 1.45000

Purity/Quality:

98%Min ^*data from raw suppliers

8-Hydroxy-3,4-dihydronaphthalen-2(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Hydroxy-2-tetralone

There total 5 articles about 8-Hydroxy-2-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

8-methoxy-2-tetralone (5309-19-3) → 8-hydroxy-2-tetralone (53568-05-1)

Guidance literature:

at 100 ℃; for 7h;

DOI:10.1002/anie.201107695

Reference yield: 11.0%

1,2,3,4-tetrahydronaphthalen-2-one (530-93-8) → 5-hydroxy-2-tetralone (35697-10-0) + 6-hydroxy-1,2,3,4-tetrahydronaphthalen-2-one (52727-28-3) + 8-hydroxy-2-tetralone (53568-05-1) + 7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-one (37827-68-2)

Guidance literature:

With dihydrogen peroxide; hydrogen fluoride; antimony pentafluoride; at -50 ℃; for 0.0333333h; Mechanism; Product distribution;

DOI:10.1016/S0040-4039(00)88104-6

Reference yield:

7-Methoxy-1-tetralone (6836-19-7) → 8-hydroxy-2-tetralone (53568-05-1)

Guidance literature:

upstream raw materials:

1,2,3,4-tetrahydronaphthalen-2-one

7-methoxynaphth-1-ol

7-Methoxy-1-tetralone

8-methoxy-2-tetralone

Downstream raw materials:

(S)-1,2,3,4-tetrahydronaphthalene-2,8-diyl bis(4-bromobenzoate)

Refernces

• 1、 Bonomi, Paolo,Cairoli, Paola,Ubiali, Daniela,Morelli, Carlo F.,Filice, Marco,Nieto, Ines,Pregnolato, Massimo,Manitto, Paolo,Terreni, Marco,Speranza, Giovanna. "Enzymatic resolution of 5-hydroxy- and 8-hydroxy-2-tetralols using immobilized lipases". scheme or table. p. 467 - 472. Retrieved 2009/09/06.
• 2、 Manitto, Paolo,Speranza, Giovanna,Monti, Diego,Fontana, Gabriele,Panosetti, Elisa. "Baker's Yeast Mediated Reduction of Aromatic Ring Substituted 2-Tetralones". . p. 11531 - 11546. Retrieved 2007/10/02.