7-METHOXY-1-NAPHTHOL

Base Information

• Chemical Name: 7-METHOXY-1-NAPHTHOL
• CAS No.: 67247-13-6
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• Hs Code.: 2909500000
• Mol file: 67247-13-6.mol

Synonyms:1-Naphthalenol,7-methoxy;1-Hydroxy-7-methoxynaphthalene;1-Oxy-7-methoxy-naphthalin;7-methoxynaphth-1-ol;7-Methoxy-1-naphthol;

Chemical Property of 7-METHOXY-1-NAPHTHOL

Chemical Property:

• Melting Point: 122-124℃
• Boiling Point: 336.7±15.0 °C(Predicted)
• PKA: 9.50±0.40(Predicted)
• PSA: 29.46000
• Density: 1.193±0.06 g/cm3(Predicted)
• LogP: 2.55400
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

7-Methoxy-1-naphthol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Methoxy-1-naphthalenol 7-Methoxy-1-naphthalenol is used in the synthesis of Agomelatine (A430000).

Technology Process of 7-METHOXY-1-NAPHTHOL

There total 16 articles about 7-METHOXY-1-NAPHTHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-methoxy-1,4-dihydro-1,4-epoxidonaphthalene (19061-33-7) → 7-methoxynaphth-1-ol (67247-13-6)

Guidance literature:

With hydrogenchloride; In methanol; for 1h; Heating;

Reference yield: 83.0%

C11H10O2 → 7-methoxynaphth-1-ol (67247-13-6)

Guidance literature:

With dichlorotricarbonylruthenium(II) dimer; In 1,2-dichloro-ethane; at 60 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo901504n

Reference yield: 74.0%

methanol (67-56-1) + 1,7-Dihydroxynaphthalene (575-38-2) → 1,7-dimethoxynaphthalene (5309-18-2) + 7-methoxynaphth-1-ol (67247-13-6)

Guidance literature:

With hydrogenchloride; for 168h; Ambient temperature;

DOI:10.1071/CH9930731

upstream raw materials:

4-(p-methoxyphenyl)-3-butenoic acid

7-methoxynaphthalen-1-amine

methanol

1,7-Dihydroxynaphthalene

Refernces

• 1、 Chen, Chang-Di,Sheng, Wen-Bing,Shi, Guo-Jun,Guo, Can-Cheng. "Substituent-induced regioselective hydroxylation of the aromatic C-H bond on naphthalene with metachloroperbenzoic acid catalyzed by F20TPPMnCl". . p. 23 - 29. Retrieved 2013/03/13.
• 2、 Ballantine, Melissa,Menard, Michelle L.,Tam, William. "Isomerization of 7-oxabenzonorbornadienes into naphthols catalyzed by [RuCl2(CO)3]2". supporting information; experimental part. p. 7570 - 7573. Retrieved 2009/12/28.