5309-18-2

Basic information

• Product Name: 1,7-DIMETHOXYNAPHTHALENE
• Synonyms: 1,7-DIMETHOXYNAPHTHALENE;Naphthalene,1,7-dimethoxy-
• CAS NO: 5309-18-2
• Molecular Formula: C₁₂H₁₂O₂
• Molecular Weight: 188.22
• EINECS: 258-258-3
• Product Categories: Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 5309-18-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 289-290 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.132 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00105mmHg at 25°C
• Refractive Index: n20/D 1.6160(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,7-DIMETHOXYNAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,7-DIMETHOXYNAPHTHALENE(5309-18-2)
• EPA Substance Registry System: 1,7-DIMETHOXYNAPHTHALENE(5309-18-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 5309-18-2(Hazardous Substances Data)

Usage

General Description

1,7-Dimethoxynaphthalene is a chemical compound that belongs to the family of aromatic hydrocarbons. It is a white solid that is insoluble in water but soluble in organic solvents. 1,7-DIMETHOXYNAPHTHALENE is commonly used as a reagent in organic synthesis, particularly in the production of dyes and pigments. It is also used in the manufacturing of pharmaceuticals and as a fragrance ingredient in perfumes and cosmetics. Additionally, 1,7-Dimethoxynaphthalene has been studied for its potential use in organic light-emitting diodes (OLEDs) due to its ability to emit light when exposed to an electrical current. Overall, this chemical compound has various industrial and research applications due to its unique properties and reactivity.

InChI:InChI=1/C12H12O2/c1-13-10-7-6-9-4-3-5-12(14-2)11(9)8-10/h3-8H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 575-38-2 1,7-Dihydroxynaphthalene 
• 108-24-7 acetic anhydride 
• 15822-95-4 4,6-dimethoxy-[2]naphthoic acid methyl ester 
• 6836-19-7 7-Methoxy-1-tetralone 
• 2059-68-9 4-bromo-1,7-dimethoxynaphthalene 
• 67247-13-6 7-methoxynaphth-1-ol 
• 77-78-1 dimethyl sulfate 
• 77746-22-6 1,7-Dimethoxy-naphthalen-2-ol 
• 67-56-1 methanol 
• 105901-89-1 4,6-Dimethoxy-naphthalin-carbonsaeure-(2) 

Downstream Products

• 126403-50-7 (Z)-2-(4,6-Dimethoxy-naphthalen-1-yl)-1,4-diphenyl-but-2-ene-1,4-dione 
• 5309-19-3 8-methoxy-2-tetralone 
• 1092963-99-9 2-acetoxymethyl-9-methoxy-1-(phenylcarbamoyl)naphtho[2,1-b]furan 
• 1092963-88-6 2-acetoxy-2-(4,6-dimethoxy-1-naphthyl)-N-phenyl-3-oxobutanamide 
• 1449306-18-6 methyl 5-methoxy-2-[(1E,3E)-3-(5-fluoro-1,3-dimethyl-2-oxo-1,3-dihydropyrimidin-4-ylidene)-1-propenyl]benzoate 
• 1449306-19-7 methyl 5-methoxy-2-[(1E,3Z)-3-(5-fluoro-1,3-dimethyl-2-oxo-1,3-dihydropyrimidin-4-ylidene)-1-propenyl]benzoate 
• 70179-60-1 3-Acetoxy-11-methoxy-18-norandrasta-3,5,8,11,13-pentaen-17-on 
• 109037-04-9 methyl-(7-phenyl-5,6-dihydro-[1]naphthyl)-ether 
• 103392-93-4 methyl-(7-phenyl-[1]naphthyl)-ether 
• 121726-87-2 5,7-dimethoxy-2-(4'-chlorophenyl)-1H-benzindole 
• 121726-83-8 5,7-dimethoxy-2-phenyl-1H-benzindole 
• 121726-91-8 5,7-dihydroxy-2-phenyl-1H-benzindole 
• 69769-77-3 6-methoxy-1-naphthylbenzyl ketone 

Relevant articles and documents

A New Practical Route for the Manufacture of (4aR, 10aR)-9-Methoxy-1- methyl-6-trimethylsilanyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline

Different synthetic routes to the enantiomerically pure octahydrobenzo[g]quinoline derivative JNZ092 were evaluated for their suitability to rapidly prepare a first clinical batch on a kilogram scale. On the basis of the experience of previous octahydrobenzo[g]quinoline projects a new linear synthesis of JNZ092 was established and scaled up successfully. The overall yield was increased by a factor 10 and the preparation time shortened significantly as compared to those of the medicinal chemistry route. As the key strategy all atoms of the octahydrobenzo[g]quinoline skeleton were introduced early by the reaction of the 6-lithiated 1,7-dimethoxynaphthalene with ethyl-2-cyano-3-ethoxyacrylate. As a valuable technological refinement the practicability of a chromatographic technique with repetitive feed injection for the problematic separation of the enantiomers was demonstrated.

Synthesis and antifungal activities of novel 2-aminotetralin derivatives

Novel 2-aminotetralin derivatives were synthesized as antifungal agents. The 2-aminotetralin scaffold was chemically designed to mimic the tetrahydroisoquinoline ring of the lead molecule described before. Their antifungal activities were evaluated in vitro by measuring the minimal inhibitory concentrations (MICs). Compounds 10a, 12a, 12c, 13b, and 13d are more potent than fluconazole against seven testing human fungal pathogens. Compound 10b exhibits much higher antifungal activities against all of the four fluconazole-resistant clinic Candida albicans strains than the control drugs including amphotericin B, terbinafine, ketoconazole, and itraconazole. The mode of action of some compounds to the potential receptor lanosterol 14α-demethylase (CYP51) was investigated by molecular docking. The studies presented here provide a new structural type for the development of novel antifungal compounds. Furthermore, 10b was evaluated in vivo by a rat vaginal candidiasis model, and it was found that 10b significantly decreases the number of fungal colony counts.

CIS-HEXAHYDRO-5-(1,2,3,4-TETRAHYDRO-2-NAPHTHALENYL)PYRROLOPYRROLES AS INHIBITORS OF SEROTONIN REUPTAKE

-