N-(4-methoxyphenyl)-1,1-diphenylmethylamine

Base Information

• Chemical Name: N-(4-methoxyphenyl)-1,1-diphenylmethylamine
• CAS No.: 6709-42-8
• Molecular Formula: C₂₀H₁₉NO
• Molecular Weight: 289.377
• Mol file: 6709-42-8.mol

Synonyms:N-(4-methoxyphenyl)-1,1-diphenylmethylamine

Chemical Property of N-(4-methoxyphenyl)-1,1-diphenylmethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methoxyphenyl)-1,1-diphenylmethylamine

There total 24 articles about N-(4-methoxyphenyl)-1,1-diphenylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(4-methoxyphenyl)-1,1-diphenylmethanimine (42834-19-5) → N-(4-methoxyphenyl)-1,1-diphenylmethylamine (6709-42-8)

Guidance literature:

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 3h; chemoselective reaction; Irradiation; Sealed tube;

DOI:10.1021/acs.orglett.7b03565

Reference yield: 93.0%

benzophenone tosylhydrazone (4545-20-4) + 4-methoxy-aniline (104-94-9) → N-(4-methoxyphenyl)-1,1-diphenylmethylamine (6709-42-8)

Guidance literature:

With copper acetylacetonate; water; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In fluorobenzene; at 120 ℃; for 2h; Sealed tube;

DOI:10.1002/adsc.201300466

Reference yield: 91.0%

benzyl(4-methoxyphenyl)amine (17377-95-6) + phenyllithium (591-51-5) → N-(4-methoxyphenyl)-1,1-diphenylmethylamine (6709-42-8)

Guidance literature:

benzyl(4-methoxyphenyl)amine; With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chlorobenzene; at 20 ℃; for 0.166667h; Inert atmosphere;

phenyllithium; In dibutyl ether; chlorobenzene; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol401534g

upstream raw materials:

4-methoxyformanilide

N-(4-methoxyphenyl)-1,1-diphenylmethanimine

[4-(benzylideneamino)phenyl]methanol

p-anisidine-ND2

Downstream raw materials:

N-benzhydryl-N-(4-methoxy-phenyl)-N'-phenyl-urea

acetic acid-(N-benzhydryl-p-anisidide)

Refernces

• 1、 He, Feifei,Empel, Claire,Koenigs, Rene M.. "Silver-Catalyzed N-H Functionalization of Aryl/Aryl Diazoalkanes with Anilines". . p. 6719 - 6723. Retrieved 2021/09/13.
• 2、 Subaramanian, Murugan,Midya, Siba P.,Ramar, Palmurukan M.,Balaraman, Ekambaram. "General synthesis of N-Alkylation of amines with secondary alcohols via hydrogen autotransfer". supporting information. p. 8899 - 8903. Retrieved 2019/11/14.