7alpha-Methyl-3,3-dimethoxy-5(10)-estrene-17-one

Base Information

• Chemical Name: 7alpha-Methyl-3,3-dimethoxy-5(10)-estrene-17-one
• CAS No.: 88247-84-1
• Molecular Formula: C21H32O3
• Molecular Weight: 332.483
• Mol file: 88247-84-1.mol

Synonyms:(7alpha)-3,3-Dimethoxy-7-methyl-estr-5(10)-en-17-one;

Chemical Property of 7alpha-Methyl-3,3-dimethoxy-5(10)-estrene-17-one

Chemical Property:

• Vapor Pressure: 1.39E-07mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 429.5 °C at 760 mmHg
• Flash Point: 205.4 °C
• PSA: 35.53000
• Density: 1.09 g/cm³
• LogP: 4.50740
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

7a-Methyl-3,3-dimethoxy-5(10)-estrene-17-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,3-Dimethoxy-7α-methylestr-5(10)-en-17-one is a reagent used for the preparationon of Tibolone(T437500). Tibolone is a synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.

Technology Process of 7alpha-Methyl-3,3-dimethoxy-5(10)-estrene-17-one

There total 3 articles about 7alpha-Methyl-3,3-dimethoxy-5(10)-estrene-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methanol (67-56-1) + 7α-methylestr-5(10)-ene-3,17-dione (105186-32-1) → 3,3-dimethoxy-7α-methylestr-5(10)-en-17-one (88247-84-1)

Guidance literature:

With malonic acid; at 20 ℃; for 24h;

DOI:10.1002/recl.19861050403

Reference yield:

17β,19-dihydroxy-7-methylandrost-4-en-3-one → 3,3-dimethoxy-7α-methylestr-5(10)-en-17-one (88247-84-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 46 percent / CrO₃, conc. H₂SO₄ / H₂O; CH₂Cl₂ / 2.75 h / 30 - 40 °C

2: 98 percent / magnesium methoxide / tetrahydrofuran; liquid ammonia / 1 h / -35 °C

3: 86 percent / malonic acid / 24 h / 20 °C

With chromium(VI) oxide; malonic acid; sulfuric acid; magnesium methanolate; In tetrahydrofuran; dichloromethane; ammonia; water;

DOI:10.1002/recl.19861050403

Reference yield:

7α-methyl-3,17-dioxoandrost-4-en-19-al (63841-74-7) → 3,3-dimethoxy-7α-methylestr-5(10)-en-17-one (88247-84-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / magnesium methoxide / tetrahydrofuran; liquid ammonia / 1 h / -35 °C

2: 86 percent / malonic acid / 24 h / 20 °C

With malonic acid; magnesium methanolate; In tetrahydrofuran; ammonia;

DOI:10.1002/recl.19861050403

upstream raw materials:

methanol

7α-methylestr-5(10)-ene-3,17-dione

7α-methyl-3,17-dioxoandrost-4-en-19-al

Downstream raw materials:

10β-hydroperoxy-17β-hydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one

10β,17β-dihydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one

tibolone

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one

Refernces