Tibolone

Base Information Edit

Chemical Name:Tibolone
CAS No.:5630-53-5
Deprecated CAS:133677-19-7
Molecular Formula:C21H28O2
Molecular Weight:312.452
Hs Code.:
European Community (EC) Number:227-069-1
UNII:FF9X0205V2
DSSTox Substance ID:DTXSID5023667
Nikkaji Number:J8.033K
Wikipedia:Tibolone
Wikidata:Q413805
NCI Thesaurus Code:C66955
Pharos Ligand ID:XJ1V3BSSG221
Metabolomics Workbench ID:54520
ChEMBL ID:CHEMBL2103774
Mol file:5630-53-5.mol

Synonyms:Boltin;Livial;Liviella;Org OD 14;Org OD14;tibilone;tibolone

Suppliers and Price of Tibolone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Tibolone ≥98% (HPLC)
50 mg
$ 49.90

Sigma-Aldrich
Tibolone for system suitability European Pharmacopoeia (EP) Reference Standard
y0000668
$ 190.00

Cayman Chemical
Tibolone
5000mg
$ 324.00

Cayman Chemical
Tibolone ≥98%
100mg
$ 17.00

Cayman Chemical
Tibolone ≥98%
500mg
$ 65.00

Cayman Chemical
Tibolone
1000mg
$ 98.00

AvaChem
Tibolone
100mg
$ 75.00

AvaChem
Tibolone
10mg
$ 35.00

AvaChem
Tibolone
1g
$ 175.00

American Custom Chemicals Corporation
TIBOLONE 95.00%
100MG
$ 1871.10

Total 134 raw suppliers

Chemical Property of Tibolone Edit

Chemical Property:

Appearance/Colour:white solid
Vapor Pressure:6.96E-10mmHg at 25°C
Melting Point:169 °C
Refractive Index:105 ° (C=0.54, CH2Cl2/Et2O)
Boiling Point:447.4 °C at 760 mmHg
PKA:13.10±0.60(Predicted)
Flash Point:190.6 °C
PSA：37.30000
Density:1.13 g/cm³
LogP:3.88260
Storage Temp.:2-8°C
Solubility.:DMSO: soluble15mg/mL, clear
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:312.208930132
Heavy Atom Count:23
Complexity:636

Purity/Quality:

99%, ^*data from raw suppliers

Tibolone ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s): N
Hazard Codes:N
Statements: 51/53
Safety Statements: 22-24/25-61

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Synthetic Estrogen
Canonical SMILES:CC1CC2=C(CCC(=O)C2)C3C1C4CCC(C4(CC3)C)(C#C)O
Isomeric SMILES:C[C@@H]1CC2=C(CCC(=O)C2)[C@@H]3[C@@H]1[C@@H]4CC[C@]([C@]4(CC3)C)(C#C)O
Recent ClinicalTrials:The Effects of Luo-Bu-Fu-Ke-Bi-RI Pill on Climacteric Syndrome in Women
Recent EU Clinical Trials:A Multicenter, Randomized, Double-Blind, Placebo- And Active-Controlled Study of DVS-233 SR for Treatment of Vasomotor Symptoms Associated with Menopause
Description Tibolone is a synthetic steroid with weak progestational and estrogenic properties, reportedly useful in controlling symptoms resulting from natural or surgical menopause. It has thus far shown no significant antithrombotic effect in post-menopausal patients.
Uses A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome
Clinical Use Tibolone is a synthetic steroid that has been shown to increase bone mineral density similar to alendronate. The U.S. FDA approval is pending; overseas, this agent is used for the treatment of menopausal symptoms as well as the prevention of osteoporosis. It is considered to be a viable alternative to conjugated equine estrogen plus micronized progesterone.

Technology Process of Tibolone

There total 24 articles about Tibolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: C₂₅H₃₆O₄

: 5630-53-5
tibolone

Guidance literature:: With sulfuric acid; In water; acetone; at 0 - 5 ℃; for 1h; Industrial scale;

Reference yield: 79.0%

: 105186-33-2
3,3-dimethoxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-17β-ol

: 1162-60-3
7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one

: 5630-53-5
tibolone

: 105186-34-3
10β-hydroperoxy-17β-hydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one

Guidance literature:: With oxalic acid; In ethanol; water; at 20 ℃; for 2h; Yields of byproduct given;
DOI:10.1002/recl.19861050403

Reference yield: 78.0%

: 15506-05-5
3-Methoxy-7α-methyl-17α-aethinyl-17β-hydroxy-Δ^2,5(10)-19-norandrastadien

: 5630-53-5
tibolone

Guidance literature:: 3-Methoxy-7α-methyl-17α-aethinyl-17β-hydroxy-Δ^2,5(10)-19-norandrastadien; With ascorbic acid; In ethanol; at 20 - 30 ℃; for 1h; Activated Carbon Darco G₆₀;

With hydrogenchloride; In ethanol; water; at 20 - 25 ℃;